Sachin Kumar, Prajjval Pratap Singh, Nagarjuna Pasupuleti, Shivanand S Shendre, Jaison Jeevan Sequeira, Idrees Babu, Mohammed S Mustak, Niraj Rai, Gyaneshwer Chaubey
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Using the fine-scaled analyses, we specifically focused on (A) the ancestry components of Lakshadweep Islands populations; (B) their relation with East, West Eurasia and South Asia; (C) the number of founding lineages and (D) the putative migration from Northern India as the paternal ancestry was closer to the North Indian populations. Our analysis of ancestry components confirmed relatively higher North Indian ancestry among the Lakshadweep population. These populations are closely related to the South Asian populations. We identified mainly a single founding population for these Islands, geographically divided into two sub-clusters. By examining the population's genetic composition and analysing the gene flow from different source populations, this study contributes to our understanding of Lakshadweep Island's evolutionary history and population dynamics. 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引用次数: 0
摘要
拉克沙德韦普群岛位于阿拉伯海东南部,由 36 个岛屿组成。由于缺乏详细的考古记录,该岛的人类定居时间尚不明确。以前对单倍体 DNA 制造者进行的遗传研究表明,该群岛的祖先与南印度和北印度人有性别差异。母系祖先表明与南印第安人的联系更密切,而父系祖先则主张与北印第安人的遗传亲缘关系。由于单倍体标记对遗传漂变更为敏感,这在岛屿种群中很明显,因此我们使用双亲高分辨率单核苷酸多态标记来重建拉克沙德韦普群岛的种群历史。 通过精细分析,我们特别关注:(A) 拉克沙德韦普群岛人口的祖先成分;(B) 他们与东、西欧亚大陆和南亚的关系;(C) 创始世系的数量;(D) 由于父系祖先更接近北印度人口,推测是从北印度迁徙而来。我们对祖先成分的分析证实,拉克沙德韦普岛人口的北印度祖先相对较多。这些人群与南亚人群关系密切。我们发现这些岛屿主要只有一个始祖人群,在地理上分为两个亚群。通过考察种群的遗传组成和分析来自不同来源种群的基因流,这项研究有助于我们了解拉克沙德韦普岛的进化历史和种群动态。这些发现揭示了各族群之间复杂的互动关系,以及他们在形成拉克沙德韦普岛人口过程中的基因贡献。
Genetic evidence for a single founding population of the Lakshadweep Islands.
Lakshadweep is an archipelago of 36 islands located in the Southeastern Arabian Sea. In the absence of a detailed archaeological record, the human settlement timing of this island is vague. Previous genetic studies on haploid DNA makers suggested sex-biased ancestry linked to North and South Indian populations. Maternal ancestry suggested a closer link with the Southern Indian, while paternal ancestry advocated the Northern Indian genetic affinity. Since the haploid markers are more sensitive to genetic drift, which is evident for the Island populations, we have used the biparental high-resolution single-nucleotide polymorphic markers to reconstruct the population history of Lakshadweep Islands. Using the fine-scaled analyses, we specifically focused on (A) the ancestry components of Lakshadweep Islands populations; (B) their relation with East, West Eurasia and South Asia; (C) the number of founding lineages and (D) the putative migration from Northern India as the paternal ancestry was closer to the North Indian populations. Our analysis of ancestry components confirmed relatively higher North Indian ancestry among the Lakshadweep population. These populations are closely related to the South Asian populations. We identified mainly a single founding population for these Islands, geographically divided into two sub-clusters. By examining the population's genetic composition and analysing the gene flow from different source populations, this study contributes to our understanding of Lakshadweep Island's evolutionary history and population dynamics. These findings shed light on the complex interactions between ethnic groups and their genetic contributions in making the Lakshadweep population.
期刊介绍:
Molecular Genetics and Genomics (MGG) publishes peer-reviewed articles covering all areas of genetics and genomics. Any approach to the study of genes and genomes is considered, be it experimental, theoretical or synthetic. MGG publishes research on all organisms that is of broad interest to those working in the fields of genetics, genomics, biology, medicine and biotechnology.
The journal investigates a broad range of topics, including these from recent issues: mechanisms for extending longevity in a variety of organisms; screening of yeast metal homeostasis genes involved in mitochondrial functions; molecular mapping of cultivar-specific avirulence genes in the rice blast fungus and more.