{"title":"清醒窦主动脉去神经大鼠血管对甲氧胺的反应性","authors":"M.R. Moyses, A.M. Cabral, E.C. Vasquez","doi":"10.1016/S0031-6989(88)80127-9","DOIUrl":null,"url":null,"abstract":"<div><p>Alterations in vascular alpha-adrenoceptor responsiveness following sinoaortic denervation was studied in conscious rats. The arterial hypertension observed in baroreceptor denervated rats decreased progressively during the 30 days of observation. A pressor hyperresponsiveness to methoxamine (10–80 μg/kg, iv), was observed 3 to 7 days after baroreceptor denervation followed by a gradual normalization of the vascular reactivity. The results indicate a possible participation of an enhanced alpha<sub>1</sub>-adrenoceptor-mediated vasoconstrictor component in the early phase of neurogenic hypertension.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 11","pages":"Pages 993-999"},"PeriodicalIF":0.0000,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80127-9","citationCount":"6","resultStr":"{\"title\":\"Vascular reactivity to methoxamine in conscious sinoaortic denervated rats\",\"authors\":\"M.R. Moyses, A.M. Cabral, E.C. Vasquez\",\"doi\":\"10.1016/S0031-6989(88)80127-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Alterations in vascular alpha-adrenoceptor responsiveness following sinoaortic denervation was studied in conscious rats. The arterial hypertension observed in baroreceptor denervated rats decreased progressively during the 30 days of observation. A pressor hyperresponsiveness to methoxamine (10–80 μg/kg, iv), was observed 3 to 7 days after baroreceptor denervation followed by a gradual normalization of the vascular reactivity. The results indicate a possible participation of an enhanced alpha<sub>1</sub>-adrenoceptor-mediated vasoconstrictor component in the early phase of neurogenic hypertension.</p></div>\",\"PeriodicalId\":19810,\"journal\":{\"name\":\"Pharmacological research communications\",\"volume\":\"20 11\",\"pages\":\"Pages 993-999\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80127-9\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031698988801279\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological research communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031698988801279","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Vascular reactivity to methoxamine in conscious sinoaortic denervated rats
Alterations in vascular alpha-adrenoceptor responsiveness following sinoaortic denervation was studied in conscious rats. The arterial hypertension observed in baroreceptor denervated rats decreased progressively during the 30 days of observation. A pressor hyperresponsiveness to methoxamine (10–80 μg/kg, iv), was observed 3 to 7 days after baroreceptor denervation followed by a gradual normalization of the vascular reactivity. The results indicate a possible participation of an enhanced alpha1-adrenoceptor-mediated vasoconstrictor component in the early phase of neurogenic hypertension.
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