María C. Martínez-Hergueta , Mario Cantó-Cerdán , Maria A. Amesty , M. Jose García-Corral , Laura Casanova-Blanquer , Ana B. Plaza-Puche , Jorge L. Alió , Jorge L. Alió del Barrio
{"title":"围手术期用强脉冲光预防和改善激光角膜屈光手术后干眼症状。随机临床试验","authors":"María C. Martínez-Hergueta , Mario Cantó-Cerdán , Maria A. Amesty , M. Jose García-Corral , Laura Casanova-Blanquer , Ana B. Plaza-Puche , Jorge L. Alió , Jorge L. Alió del Barrio","doi":"10.1016/j.apjo.2023.100029","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the efficacy of perioperative IPL therapy in preventing postoperative ocular surface disorders in patients undergoing corneal laser refractive surgery.</p></div><div><h3>Design</h3><p>randomized, controlled, clinical trial with triple-blinding.</p></div><div><h3>Methods</h3><p><em>Setting</em>: Vissum Miranza - Alicante; <em>Study population</em>: 61 patients randomized in two groups: 31 study patients (perioperative IPL + laser refractive surgery) and 30 control patients (perioperative placebo + laser refractive surgery). Follow-up was conducted over a 6-month period; <em>Intervention:</em> Each participants underwent three IPL sessions with a two-week interval between each session (pre-surgery, post-surgery week-one, and post-surgery week-three). For controls, placebo was administered following the same protocol. <em>Main outcomes measures</em>: visual outcomes and refraction, slit-lamp examination, corneal topography, visual analogue scale questionnaire and Oculus Keratograph 5 M including tear meniscus height, non-invasive tear break- up time, ocular redness, infrared meibography and Ocular Surface Disease Index (OSDI) questionnaire.</p></div><div><h3>Results</h3><p>61 randomized eyes were included. No significant differences were observed in terms of uncorrected and corrected distance visual acuity (UDVA, CDVA), refractive error or corneal aberrations. A statistically significant improvement in OSDI score (change −8.47, p = 0.043), tear meniscus (change 0.05 mm, p = 0.004) and Meibography (change −0.42, p = 0.012) was observed at the third postoperative month in the study group. Additionally, at the sixth postoperative month, there were statistically significant improvements in tear meniscus (change 0.06 mm, p = 0.018), tear break-up-time (change 1.68 s, p = 0.039) and Meibography (change −0.37, p = 0.030).</p></div><div><h3>Conclusions</h3><p>Results suggest that perioperative IPL therapy applied to laser corneal refractive surgery improves objective and subjective ocular surface parameters over non-IPL-treated control patients and early postoperative dry eye symptoms.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000294/pdfft?md5=1085007efef0299aa01c2f92ff7a82ae&pid=1-s2.0-S2162098923000294-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Perioperative intense pulsed light to prevent and improve symptoms of post-laser corneal refractive surgery dry eye. 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Follow-up was conducted over a 6-month period; <em>Intervention:</em> Each participants underwent three IPL sessions with a two-week interval between each session (pre-surgery, post-surgery week-one, and post-surgery week-three). For controls, placebo was administered following the same protocol. <em>Main outcomes measures</em>: visual outcomes and refraction, slit-lamp examination, corneal topography, visual analogue scale questionnaire and Oculus Keratograph 5 M including tear meniscus height, non-invasive tear break- up time, ocular redness, infrared meibography and Ocular Surface Disease Index (OSDI) questionnaire.</p></div><div><h3>Results</h3><p>61 randomized eyes were included. No significant differences were observed in terms of uncorrected and corrected distance visual acuity (UDVA, CDVA), refractive error or corneal aberrations. A statistically significant improvement in OSDI score (change −8.47, p = 0.043), tear meniscus (change 0.05 mm, p = 0.004) and Meibography (change −0.42, p = 0.012) was observed at the third postoperative month in the study group. 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Perioperative intense pulsed light to prevent and improve symptoms of post-laser corneal refractive surgery dry eye. A randomized clinical trial
Purpose
To evaluate the efficacy of perioperative IPL therapy in preventing postoperative ocular surface disorders in patients undergoing corneal laser refractive surgery.
Design
randomized, controlled, clinical trial with triple-blinding.
Methods
Setting: Vissum Miranza - Alicante; Study population: 61 patients randomized in two groups: 31 study patients (perioperative IPL + laser refractive surgery) and 30 control patients (perioperative placebo + laser refractive surgery). Follow-up was conducted over a 6-month period; Intervention: Each participants underwent three IPL sessions with a two-week interval between each session (pre-surgery, post-surgery week-one, and post-surgery week-three). For controls, placebo was administered following the same protocol. Main outcomes measures: visual outcomes and refraction, slit-lamp examination, corneal topography, visual analogue scale questionnaire and Oculus Keratograph 5 M including tear meniscus height, non-invasive tear break- up time, ocular redness, infrared meibography and Ocular Surface Disease Index (OSDI) questionnaire.
Results
61 randomized eyes were included. No significant differences were observed in terms of uncorrected and corrected distance visual acuity (UDVA, CDVA), refractive error or corneal aberrations. A statistically significant improvement in OSDI score (change −8.47, p = 0.043), tear meniscus (change 0.05 mm, p = 0.004) and Meibography (change −0.42, p = 0.012) was observed at the third postoperative month in the study group. Additionally, at the sixth postoperative month, there were statistically significant improvements in tear meniscus (change 0.06 mm, p = 0.018), tear break-up-time (change 1.68 s, p = 0.039) and Meibography (change −0.37, p = 0.030).
Conclusions
Results suggest that perioperative IPL therapy applied to laser corneal refractive surgery improves objective and subjective ocular surface parameters over non-IPL-treated control patients and early postoperative dry eye symptoms.
期刊介绍：
The Asia-Pacific Journal of Ophthalmology, a bimonthly, peer-reviewed online scientific publication, is an official publication of the Asia-Pacific Academy of Ophthalmology (APAO), a supranational organization which is committed to research, training, learning, publication and knowledge and skill transfers in ophthalmology and visual sciences. The Asia-Pacific Journal of Ophthalmology welcomes review articles on currently hot topics, original, previously unpublished manuscripts describing clinical investigations, clinical observations and clinically relevant laboratory investigations, as well as .perspectives containing personal viewpoints on topics with broad interests. Editorials are published by invitation only. Case reports are generally not considered. The Asia-Pacific Journal of Ophthalmology covers 16 subspecialties and is freely circulated among individual members of the APAO’s member societies, which amounts to a potential readership of over 50,000.
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