Magdalena Kulus, Maryam Farzaneh, Artur Bryja, Mojtaba Zehtabi, Shirin Azizidoost, Mahrokh Abouali Gale Dari, Afsaneh Golcar-Narenji, Hanna Ziemak, Mikołaj Chwarzyński, Hanna Piotrowska-Kempisty, Piotr Dzięgiel, Maciej Zabel, Paul Mozdziak, Dorota Bukowska, Bartosz Kempisty, Paweł Antosik
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引用次数: 0
摘要
上皮-间质转化(EMT)是恶性肿瘤转移的一个重要过程。正是通过获得可塑性,癌细胞才变得更具流动性,并获得向其他组织转移的能力。间充质-上皮转化(MET)是恢复到上皮状态,从而形成继发性肿瘤。EMT和MET这两个过程受不同途径和不同介质的调控,从而影响整个肿瘤发生过程的复杂程度。此外,癌症干细胞及其在血管生成过程中的参与也不容忽视,这在肿瘤内发生得非常频繁。有效治疗癌症的困难主要取决于癌细胞迅速扩张并占据第二重要器官的潜力。由于这些细胞具有扩散能力,因此出现了循环肿瘤细胞(CTC)的概念。有趣的是,即使是来自单个患者的原发肿瘤组织,CTC 也表现出分子多样性、干样和间充质特征。EMT是肿瘤转移的必要条件,而MET则是CTC建立第二部位的必要条件。透彻了解恶性肿瘤中 EMT 和 MET 之间的平衡过程至关重要。
Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells.
Epithelial-mesenchymal transition (EMT) is a crucial process with significance in the metastasis of malignant tumors. It is through the acquisition of plasticity that cancer cells become more mobile and gain the ability to metastasize to other tissues. The mesenchymal-epithelial transition (MET) is the return to an epithelial state, which allows for the formation of secondary tumors. Both processes, EMT and MET, are regulated by different pathways and different mediators, which affects the sophistication of the overall tumorigenesis process. Not insignificant are also cancer stem cells and their participation in the angiogenesis, which occur very intensively within tumors. Difficulties in effectively treating cancer are primarily dependent on the potential of cancer cells to rapidly expand and occupy secondarily vital organs. Due to the ability of these cells to spread, the concept of the circulating tumor cell (CTC) has emerged. Interestingly, CTCs exhibit molecular diversity and stem-like and mesenchymal features, even when derived from primary tumor tissue from a single patient. While EMT is necessary for metastasis, MET is required for CTCs to establish a secondary site. A thorough understanding of the processes that govern the balance between EMT and MET in malignancy is crucial.
期刊介绍:
The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication:
i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field.
ii) full length and short reports presenting original experimental work.
iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics.
iv) papers focused on diseases of stem cells.
v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale.
vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research.
vii) letters to the editor and correspondence.
In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on:
i) the role of adult stem cells in tissue regeneration;
ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development;
iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells;
iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis;
v) the role of stem cells in aging processes and cancerogenesis.