通过合理的环境操作优化微生物功能。

IF 2.6 2区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Microbiology Pub Date : 2024-09-01 Epub Date: 2024-02-19 DOI:10.1111/mmi.15236
Álvaro Sánchez, Andrea Arrabal, Magdalena San Román, Juan Díaz-Colunga
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引用次数: 0

摘要

微生物在生物技术中发挥着核心作用,因此,我们必须制定策略,对其功能进行工程设计和优化。为此,我们的大部分努力都集中在对微生物进行遗传操作,然后让它们在单种培养或混种联合体中生长。优化微生物过程的另一种策略是合理设计微生物的生长环境。微生物环境是多维的,包括温度、pH 值、盐度、营养成分等因素。这些环境因素都会影响微生物的生长和表型,而且它们通常会相互 "作用",以复杂、非相加的方式结合在一起。在这篇文章中,我们将概述这些环境因素之间 "相互作用 "的起源和后果,并讨论如何将它们纳入微生物功能的自下而上的统计预测模型,以确定单一培养物和微生物联合体的最佳环境条件。我们还概述了其他 "自上而下 "的方法,如遗传算法,以寻找环境因素的最佳组合。通过对这一领域的现状进行简要总结,我们希望能激励人们进一步开展合理操纵和优化微生物环境的工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The optimization of microbial functions through rational environmental manipulations.

The optimization of microbial functions through rational environmental manipulations.

Microorganisms play a central role in biotechnology and it is key that we develop strategies to engineer and optimize their functionality. To this end, most efforts have focused on introducing genetic manipulations in microorganisms which are then grown either in monoculture or in mixed-species consortia. An alternative strategy to optimize microbial processes is to rationally engineer the environment in which microbes grow. The microbial environment is multidimensional, including factors such as temperature, pH, salinity, nutrient composition, etc. These environmental factors all influence the growth and phenotypes of microorganisms and they generally "interact" with one another, combining their effects in complex, non-additive ways. In this piece, we overview the origins and consequences of these "interactions" between environmental factors and discuss how they have been built into statistical, bottom-up predictive models of microbial function to identify optimal environmental conditions for monocultures and microbial consortia. We also overview alternative "top-down" approaches, such as genetic algorithms, to finding optimal combinations of environmental factors. By providing a brief summary of the state of this field, we hope to stimulate further work on the rational manipulation and optimization of the microbial environment.

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来源期刊
Molecular Microbiology
Molecular Microbiology 生物-生化与分子生物学
CiteScore
7.20
自引率
5.60%
发文量
132
审稿时长
1.7 months
期刊介绍: Molecular Microbiology, the leading primary journal in the microbial sciences, publishes molecular studies of Bacteria, Archaea, eukaryotic microorganisms, and their viruses. Research papers should lead to a deeper understanding of the molecular principles underlying basic physiological processes or mechanisms. Appropriate topics include gene expression and regulation, pathogenicity and virulence, physiology and metabolism, synthesis of macromolecules (proteins, nucleic acids, lipids, polysaccharides, etc), cell biology and subcellular organization, membrane biogenesis and function, traffic and transport, cell-cell communication and signalling pathways, evolution and gene transfer. Articles focused on host responses (cellular or immunological) to pathogens or on microbial ecology should be directed to our sister journals Cellular Microbiology and Environmental Microbiology, respectively.
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