沙特阿拉伯各地的 C 型血红蛋白流行率:流行病学调查。

IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Mansour Aljabry, Suha Sulimani, Ghazi Alotaibi, Hassan Aljabri, Shaker Alomary, Izzeldin Adam, Omar Aljabri, Mansour Khater Alzahrani, Abdulrahman Alsultan
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引用次数: 0

摘要

简介HbC 是一种常见的结构性血红蛋白病,尤其是在西非。HbC 在沙特阿拉伯的发病率和地区分布尚未得到广泛证实。同型 HbC 患者可能会出现轻度溶血性贫血,而与血红蛋白 S(HbS)结合则会导致临床上严重的表型。目的:目前的流行病学研究被认为是沙特阿拉伯最大的流行病学研究,旨在评估 2011 年至 2018 年参加婚前筛查计划的夫妇中 HbC 变体的地区流行率:从 PMSGC 计划中获取婚前筛查和遗传咨询数据。然后将收集到的数据输入 SEHA 平台,该平台是沙特阿拉伯 13 个指定地区的中央电子储存库。血红蛋白电泳样本采用高效液相色谱法、毛细管电泳法或两种方法相结合的方法进行分析,以确认是否存在异常血红蛋白条带:本研究纳入了 2011 年至 2018 年的 1,871,184 人。其中,49.8%为男性,50.2%为女性。112618人(6.0%)检测结果异常。Hb C 病例总数为 778 例(0.04%)。在 764 名参与者中检测出 HbC 特质(HbAC),而同型 HbC(HbCC)和合并杂合子(HbSC)病例分别为 9 例和 5 例。红海附近地区的发病率高于中部和东部地区:结论:在沙特阿拉伯,HbC 是一种罕见的变异型,各地区的发病率各不相同。HbC变异体在麦加和麦地那地区更为常见。HbC 分布的地理区域与 HbS 流行率高的地区不同,这也解释了为什么 HbSC 病例极为罕见。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regional Prevalence of Hemoglobin C Across Saudi Arabia: An Epidemiological Survey.

Introduction: HbC is a common structural hemoglobinopathy especially in West Africa. Prevalence and regional distribution of HbC in Saudi Arabia are widely undocumented. Patients with homozygous HbC disease may have mild hemolytic anemia whereas combination with hemoglobin S (HbS) leads to a clinically severe phenotype.

Aim: The current epidemiological study, considered the largest from Saudi Arabia, aimed to evaluate the regional prevalence of the HbC variant among the couples participating in the premarital screening program from 2011 to 2018.

Methods: Data from the PMSGC program were obtained for premarital screening and genetic counseling. The collected data were then entered into the SEHA platform, a centralized electronic repository for the 13 designated regions in Saudi Arabia. Hemoglobin electrophoresis samples are analyzed using either HPLC, capillary electrophoresis, or a combination of both methods to confirm the presence of abnormal hemoglobin bands.

Results: This study included 1,871,184 individuals from 2011 to 2018. Of those, 49.8% were males and 50.2% were females. 112,618 (6.0%) had an abnormal test. Total number of Hb C cases were 778 (0.04%). HbC trait (HbAC) was detected in 764 participants while homozygous HbC (HbCC) and combined heterozygous (HbSC) were found in 9 and 5 cases, respectively. The regions near the Red Sea have higher rates than the central and eastern regions.

Conclusion: HbC is a rare variant in Saudi Arabia with varying regional frequencies. HbC variant is more common in Mecca and Madina regions. The geographic area of HbC distribution differs from the areas with high prevalence of HbS, which explains why HbSC disease cases are overwhelmingly rare.

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来源期刊
CiteScore
10.70
自引率
1.40%
发文量
57
审稿时长
19 weeks
期刊介绍: The Journal of Epidemiology and Global Health is an esteemed international publication, offering a platform for peer-reviewed articles that drive advancements in global epidemiology and international health. Our mission is to shape global health policy by showcasing cutting-edge scholarship and innovative strategies.
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