新生儿 SARS CoV-2 感染的垂直传播可能性。

IF 0.8 Q4 PEDIATRICS
AJP Reports Pub Date : 2024-02-18 eCollection Date: 2024-01-01 DOI:10.1055/s-0044-1779030
Andre A Robinson, Samantha Feder, Sushma Krishna, Lois Brustman
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引用次数: 0

摘要

母体感染严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)会影响胎盘功能,但宫内传播的可能性一直存在争议。多位学者公布了垂直传播的纳入标准,但能满足建议要求的报告却寥寥无几。尽管大多数受感染母亲所生的胎儿情况良好,但也有一些胎儿病情危重。我们介绍了一例新生儿可能经宫内传播的病例,其母亲最近出现症状,SARS CoV-2 聚合酶链反应(PCR)呈阳性。产妇主诉胎动减少,在妊娠 31 2/7 周时出现,生物物理特征评分为 2/10,需要紧急剖宫产。新生儿在出生后第 4 天出现严重的白细胞减少症,并伴有败血症症状,SARS CoV-2 PCR 呈阳性,其他检查结果均为阴性。要达到经胎盘传播的标准,需要及时收集多项诊断研究结果,而这些结果并不是标准的护理方法。需要进一步的研究来支持宫内/经胎盘感染是可能的这一观点。分娩后应尽快采集拭子,以帮助诊断新生儿感染,因为早期诊断对于帮助确定干预机会至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Likely Vertical Transmission of Neonatal SARS CoV-2 Infection.

Maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can affect placental function, but the possibility of intrauterine transmission has been debated. Several authors have published inclusion criteria for vertical transmission, but few reports exist that are able to meet the suggested requirements. Despite the fact that the majority of fetuses born to infected mothers do well, others become critically ill. We present a case of likely intrauterine transmission of a neonate born to a mother who was recently symptomatic with a positive SARS CoV-2 polymerase chain reaction (PCR). The parturient complained of decreased fetal movement and presented at 31 2/7 weeks' gestation with a biophysical profile score of 2/10 and required an emergency cesarean delivery. The neonate went on to develop severe leukopenia with signs of sepsis with a positive SARS CoV-2 PCR on day 4 of life and an otherwise pan-negative workup. Meeting criteria for transplacental transmission requires timely collection of several diagnostic studies that are not standard of care. Further research is needed to support the notion that intrauterine/transplacental infection is possible. Collection swabs should be obtained soon after delivery to help diagnose neonatal infection because early diagnosis is crucial to help identify opportunities for intervention.

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来源期刊
AJP Reports
AJP Reports PEDIATRICS-
CiteScore
2.20
自引率
0.00%
发文量
30
审稿时长
12 weeks
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