左手 RNA 四重链引导基因沉默。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI:10.1016/j.tibs.2024.01.009

Samuel E. Butcher

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引用次数: 0

摘要

多聚（UG）或 "pUG "二核苷酸重复序列通过采用不寻常的四重结构，在秀丽隐杆线虫体内引导基因沉默。人类有数以千计的 pUG 序列和与它们相互作用的蛋白质。pUG 折叠揭示了基因调控和 RNA 折叠的新方面，突出了简单序列如何编码复杂结构。

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A left-handed RNA quadruplex directs gene silencing

Poly(UG) or ‘pUG’ dinucleotide repeats direct gene silencing in Caenorhabditis elegans by adopting an unusual quadruplex structure. Humans have thousands of pUG sequences and proteins that interact with them. The pUG fold reveals new aspects of gene regulation and RNA folding, highlighting how a simple sequence can encode a complex structure.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.