Sabine BR. Kästner , Thomas Amon , Julia Tünsmeyer , Mike Noll , Franz-Josef Söbbeler , Sirpa Laakso , Lasse Saloranta , Mirja Huhtinen
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TP: tasipimidine 30 μg kg<sup>–1</sup> (PO) 60 minutes before induction of anaesthesia followed by placebo (NaCl 0.9%) IV. TMP: tasipimidine 30 μg kg<sup>–1</sup> PO 60 minutes before induction of anaesthesia followed by methadone 0.2 mg kg<sup>–1</sup> IV. TMPD: tasipimidine 30 μg kg<sup>–1</sup> PO 60 minutes before induction of anaesthesia followed by methadone 0.2 mg kg<sup>–1</sup> and dexmedetomidine 1 μg kg<sup>–1</sup> IV followed by a dexmedetomidine constant rate infusion of 1 μg kg<sup>–1</sup> hour<sup>–1</sup>.</p><p>Sedation, response to catheter placement, intubation quality, time to loss of consciousness, time to intubation, required dose of propofol and minimum alveolar isoflurane concentration preventing motor movement (MAC<sub>NM</sub>) were determined.</p><p>A mixed-model analysis or the Friedman and Mann–Whitney test were used; <em>p</em>-value < 0.05.</p></div><div><h3>Results</h3><p>Response to catheter placement did not differ between treatments. Tasipimidine alone reduced the propofol dose by 30%. Addition of methadone or methadone and dexmedetomidine reduced the propofol dose by 48% and 50%, respectively. Isoflurane MAC<sub>NM</sub> was reduced by 19% in tasipimidine-medicated dogs, whereas in combination with methadone or methadone and dexmedetomidine, isoflurane MAC<sub>NM</sub> was reduced by 35%.</p></div><div><h3>Conclusions and clinical relevance</h3><p>An anxiolytic dose of tasipimidine induced mild signs of sedation in dogs and reduced propofol and isoflurane requirements to induce and maintain anaesthesia, which needs to be considered in an anaesthetic plan.</p></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1467298724000060/pdfft?md5=0b3fe5e6e783f3f57e4fe5557652f997&pid=1-s2.0-S1467298724000060-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Anaesthetic-sparing effect of the anxiolytic drug tasipimidine in Beagle dogs\",\"authors\":\"Sabine BR. Kästner , Thomas Amon , Julia Tünsmeyer , Mike Noll , Franz-Josef Söbbeler , Sirpa Laakso , Lasse Saloranta , Mirja Huhtinen\",\"doi\":\"10.1016/j.vaa.2024.02.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To evaluate the effect of oral tasipimidine on dog handling, ease of catheter placement and propofol and isoflurane requirements for anaesthesia.</p></div><div><h3>Study design</h3><p>Placebo-controlled, randomized, blinded, experimental trial.</p></div><div><h3>Animals</h3><p>A group of seven adult Beagle dogs weighing (mean ± standard deviation) 13.1 ± 2.7 kg with a mean age of 18.6 ± 1 months.</p></div><div><h3>Methods</h3><p>The dogs underwent four treatments before induction of anaesthesia with propofol. PP: placebo orally (PO) 60 minutes before induction of anaesthesia followed by placebo (NaCl 0.9%) intravenously (IV). TP: tasipimidine 30 μg kg<sup>–1</sup> (PO) 60 minutes before induction of anaesthesia followed by placebo (NaCl 0.9%) IV. TMP: tasipimidine 30 μg kg<sup>–1</sup> PO 60 minutes before induction of anaesthesia followed by methadone 0.2 mg kg<sup>–1</sup> IV. TMPD: tasipimidine 30 μg kg<sup>–1</sup> PO 60 minutes before induction of anaesthesia followed by methadone 0.2 mg kg<sup>–1</sup> and dexmedetomidine 1 μg kg<sup>–1</sup> IV followed by a dexmedetomidine constant rate infusion of 1 μg kg<sup>–1</sup> hour<sup>–1</sup>.</p><p>Sedation, response to catheter placement, intubation quality, time to loss of consciousness, time to intubation, required dose of propofol and minimum alveolar isoflurane concentration preventing motor movement (MAC<sub>NM</sub>) were determined.</p><p>A mixed-model analysis or the Friedman and Mann–Whitney test were used; <em>p</em>-value < 0.05.</p></div><div><h3>Results</h3><p>Response to catheter placement did not differ between treatments. Tasipimidine alone reduced the propofol dose by 30%. Addition of methadone or methadone and dexmedetomidine reduced the propofol dose by 48% and 50%, respectively. 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A group of seven adult Beagle dogs weighing (mean ± standard deviation) 13.1 ± 2.7 kg with a mean age of 18.6 ± 1 months.
Methods
The dogs underwent four treatments before induction of anaesthesia with propofol. PP: placebo orally (PO) 60 minutes before induction of anaesthesia followed by placebo (NaCl 0.9%) intravenously (IV). TP: tasipimidine 30 μg kg–1 (PO) 60 minutes before induction of anaesthesia followed by placebo (NaCl 0.9%) IV. TMP: tasipimidine 30 μg kg–1 PO 60 minutes before induction of anaesthesia followed by methadone 0.2 mg kg–1 IV. TMPD: tasipimidine 30 μg kg–1 PO 60 minutes before induction of anaesthesia followed by methadone 0.2 mg kg–1 and dexmedetomidine 1 μg kg–1 IV followed by a dexmedetomidine constant rate infusion of 1 μg kg–1 hour–1.
Sedation, response to catheter placement, intubation quality, time to loss of consciousness, time to intubation, required dose of propofol and minimum alveolar isoflurane concentration preventing motor movement (MACNM) were determined.
A mixed-model analysis or the Friedman and Mann–Whitney test were used; p-value < 0.05.
Results
Response to catheter placement did not differ between treatments. Tasipimidine alone reduced the propofol dose by 30%. Addition of methadone or methadone and dexmedetomidine reduced the propofol dose by 48% and 50%, respectively. Isoflurane MACNM was reduced by 19% in tasipimidine-medicated dogs, whereas in combination with methadone or methadone and dexmedetomidine, isoflurane MACNM was reduced by 35%.
Conclusions and clinical relevance
An anxiolytic dose of tasipimidine induced mild signs of sedation in dogs and reduced propofol and isoflurane requirements to induce and maintain anaesthesia, which needs to be considered in an anaesthetic plan.
期刊介绍：
Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome:
the basic sciences;
pathophysiology of disease as it relates to anaesthetic management
equipment
intensive care
chemical restraint of animals including laboratory animals, wildlife and exotic animals
welfare issues associated with pain and distress
education in veterinary anaesthesia and analgesia.
Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.
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