Shan R. Nawarathne , Hyesuk Kim , Myunghwan Yu , Hyun-Min Cho , Jun-Seon Hong , Yubin Kim , Samiru S. Wickramasuriya , Sungtaek Oh , Kyu-Yeol Son , Min-Ah Park , Kyungmin Lee , Hwi-Jae Kim , Young-Joo Yi , Jung-Min Heo
{"title":"膳食中的黄连素可抑制实验性球虫病对肉鸡的有害影响","authors":"Shan R. Nawarathne , Hyesuk Kim , Myunghwan Yu , Hyun-Min Cho , Jun-Seon Hong , Yubin Kim , Samiru S. Wickramasuriya , Sungtaek Oh , Kyu-Yeol Son , Min-Ah Park , Kyungmin Lee , Hwi-Jae Kim , Young-Joo Yi , Jung-Min Heo","doi":"10.1016/j.japr.2024.100416","DOIUrl":null,"url":null,"abstract":"<div><p>Poultry coccidiosis is a catastrophic parasitic disease and the industry is currently seeking alternative compounds to replace conventional antibiotics. Accordingly, the current study determined the effect of dietary violacein supplementation on growth performance and anticoccidial indices of <em>Eimeria</em>-infected broiler chickens. A total of 336-day-old “Ross 308” broiler chicks were allotted to 6 treatments: that is, positive control (<strong>PC</strong>), negative control (<strong>NC</strong>), 1 treatment with salinomycin (6 ppm), and 3 treatments with different violacein concentrations (10, 15, 20 ppm). Experimental coccidiosis was induced in all chickens (except NC) by inoculating 3.2 × 10<sup>5</sup> sporulated oocysts. The treatment with 15 ppm violacein (<strong>VIO 15</strong>) significantly improved chicken growth performance compared to PC. Furthermore, significant reductions in lesion score, oocyst per gram of feces (<strong>OPG</strong>), and oocysts index (<strong>OI</strong>) were observed in the VIO 15 and the salinomycin treatments compared to other treatments. Violacein was reported as ‘moderately effective’ on <em>Eimeria</em> spp. based on the “anticoccidial index (<strong>ACI</strong>),” whereas “reduction in lesion score (<strong>RLS</strong>)” and “percentage anticoccidial activity (<strong>POAA</strong>)” indices designated its 15 ppm treatment as “highly sensitive” on them. Additionally, VIO 15 downregulated “interleukin-8 (<strong>IL-8</strong>)” and “interleukin-6 (<strong>IL-6</strong>)” compared to PC, in both spleen and cecal tonsils. Besides, expression levels of “chemokine C–C motif ligand 2 (<strong>CCLi-2</strong>),” were reduced in cecal tonsils of VIO 15 broiler chickens compared to PC. Conclusively, dietary violacein supplementation suppressed the deleterious effects of coccidial infection in broiler chickens with improved growth, and its 15 ppm level is recommended for use.</p></div>","PeriodicalId":15240,"journal":{"name":"Journal of Applied Poultry Research","volume":"33 2","pages":"Article 100416"},"PeriodicalIF":1.6000,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056617124000151/pdfft?md5=0b6463c0a97ee3063cf1460e9e765484&pid=1-s2.0-S1056617124000151-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Dietary violacein suppresses the deleterious effects of experimentally induced coccidiosis in broiler chickens\",\"authors\":\"Shan R. Nawarathne , Hyesuk Kim , Myunghwan Yu , Hyun-Min Cho , Jun-Seon Hong , Yubin Kim , Samiru S. Wickramasuriya , Sungtaek Oh , Kyu-Yeol Son , Min-Ah Park , Kyungmin Lee , Hwi-Jae Kim , Young-Joo Yi , Jung-Min Heo\",\"doi\":\"10.1016/j.japr.2024.100416\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Poultry coccidiosis is a catastrophic parasitic disease and the industry is currently seeking alternative compounds to replace conventional antibiotics. Accordingly, the current study determined the effect of dietary violacein supplementation on growth performance and anticoccidial indices of <em>Eimeria</em>-infected broiler chickens. A total of 336-day-old “Ross 308” broiler chicks were allotted to 6 treatments: that is, positive control (<strong>PC</strong>), negative control (<strong>NC</strong>), 1 treatment with salinomycin (6 ppm), and 3 treatments with different violacein concentrations (10, 15, 20 ppm). Experimental coccidiosis was induced in all chickens (except NC) by inoculating 3.2 × 10<sup>5</sup> sporulated oocysts. The treatment with 15 ppm violacein (<strong>VIO 15</strong>) significantly improved chicken growth performance compared to PC. Furthermore, significant reductions in lesion score, oocyst per gram of feces (<strong>OPG</strong>), and oocysts index (<strong>OI</strong>) were observed in the VIO 15 and the salinomycin treatments compared to other treatments. Violacein was reported as ‘moderately effective’ on <em>Eimeria</em> spp. based on the “anticoccidial index (<strong>ACI</strong>),” whereas “reduction in lesion score (<strong>RLS</strong>)” and “percentage anticoccidial activity (<strong>POAA</strong>)” indices designated its 15 ppm treatment as “highly sensitive” on them. Additionally, VIO 15 downregulated “interleukin-8 (<strong>IL-8</strong>)” and “interleukin-6 (<strong>IL-6</strong>)” compared to PC, in both spleen and cecal tonsils. Besides, expression levels of “chemokine C–C motif ligand 2 (<strong>CCLi-2</strong>),” were reduced in cecal tonsils of VIO 15 broiler chickens compared to PC. 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Dietary violacein suppresses the deleterious effects of experimentally induced coccidiosis in broiler chickens
Poultry coccidiosis is a catastrophic parasitic disease and the industry is currently seeking alternative compounds to replace conventional antibiotics. Accordingly, the current study determined the effect of dietary violacein supplementation on growth performance and anticoccidial indices of Eimeria-infected broiler chickens. A total of 336-day-old “Ross 308” broiler chicks were allotted to 6 treatments: that is, positive control (PC), negative control (NC), 1 treatment with salinomycin (6 ppm), and 3 treatments with different violacein concentrations (10, 15, 20 ppm). Experimental coccidiosis was induced in all chickens (except NC) by inoculating 3.2 × 105 sporulated oocysts. The treatment with 15 ppm violacein (VIO 15) significantly improved chicken growth performance compared to PC. Furthermore, significant reductions in lesion score, oocyst per gram of feces (OPG), and oocysts index (OI) were observed in the VIO 15 and the salinomycin treatments compared to other treatments. Violacein was reported as ‘moderately effective’ on Eimeria spp. based on the “anticoccidial index (ACI),” whereas “reduction in lesion score (RLS)” and “percentage anticoccidial activity (POAA)” indices designated its 15 ppm treatment as “highly sensitive” on them. Additionally, VIO 15 downregulated “interleukin-8 (IL-8)” and “interleukin-6 (IL-6)” compared to PC, in both spleen and cecal tonsils. Besides, expression levels of “chemokine C–C motif ligand 2 (CCLi-2),” were reduced in cecal tonsils of VIO 15 broiler chickens compared to PC. Conclusively, dietary violacein supplementation suppressed the deleterious effects of coccidial infection in broiler chickens with improved growth, and its 15 ppm level is recommended for use.
期刊介绍：
The Journal of Applied Poultry Research (JAPR) publishes original research reports, field reports, and reviews on breeding, hatching, health and disease, layer management, meat bird processing and products, meat bird management, microbiology, food safety, nutrition, environment, sanitation, welfare, and economics. As of January 2020, JAPR will become an Open Access journal with no subscription charges, meaning authors who publish here can make their research immediately, permanently, and freely accessible worldwide while retaining copyright to their work. Papers submitted for publication after October 1, 2019 will be published as Open Access papers.
The readers of JAPR are in education, extension, industry, and government, including research, teaching, administration, veterinary medicine, management, production, quality assurance, product development, and technical services. Nutritionists, breeder flock supervisors, production managers, microbiologists, laboratory personnel, food safety and sanitation managers, poultry processing managers, feed manufacturers, and egg producers use JAPR to keep up with current applied poultry research.
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