利用诱导多能干细胞衍生的肌肉干细胞治疗杜兴氏肌肉萎缩症的细胞疗法和再生康复的潜力

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Nana Takenaka-Ninagawa , Megumi Goto , Clémence Kiho Bourgeois Yoshioka , Mayuho Miki , Hidetoshi Sakurai
{"title":"利用诱导多能干细胞衍生的肌肉干细胞治疗杜兴氏肌肉萎缩症的细胞疗法和再生康复的潜力","authors":"Nana Takenaka-Ninagawa ,&nbsp;Megumi Goto ,&nbsp;Clémence Kiho Bourgeois Yoshioka ,&nbsp;Mayuho Miki ,&nbsp;Hidetoshi Sakurai","doi":"10.1016/j.cobme.2024.100523","DOIUrl":null,"url":null,"abstract":"<div><p>Duchenne muscular dystrophy (DMD) is a hereditary disease characterized by severe muscle weakness resulting from DYSTROPHIN deficiency-associated damage. Muscle regeneration therapy using skeletal muscle stem cell (MuSC) transplantation has demonstrated great promise. Optimized differentiation methods yield efficient induced pluripotent stem cell-derived MuSCs (iMuSCs); transplanted iMuSCs have high regenerative potential in DMD mouse models. However, achieving complete pathophysiological recovery of DMD motor function through cell therapy alone is challenging. According to recent studies, exercise can significantly improve DMD pathophysiology. Current research aims to enhance therapeutic efficacy by combining cell transplantation with exercise interventions, addressing the limitations of cell-transplantation therapy for DMD.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cell therapy for duchenne muscular dystrophy using induced pluripotent stem cell-derived muscle stem cells and the potential of regenerative rehabilitation\",\"authors\":\"Nana Takenaka-Ninagawa ,&nbsp;Megumi Goto ,&nbsp;Clémence Kiho Bourgeois Yoshioka ,&nbsp;Mayuho Miki ,&nbsp;Hidetoshi Sakurai\",\"doi\":\"10.1016/j.cobme.2024.100523\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Duchenne muscular dystrophy (DMD) is a hereditary disease characterized by severe muscle weakness resulting from DYSTROPHIN deficiency-associated damage. Muscle regeneration therapy using skeletal muscle stem cell (MuSC) transplantation has demonstrated great promise. Optimized differentiation methods yield efficient induced pluripotent stem cell-derived MuSCs (iMuSCs); transplanted iMuSCs have high regenerative potential in DMD mouse models. However, achieving complete pathophysiological recovery of DMD motor function through cell therapy alone is challenging. According to recent studies, exercise can significantly improve DMD pathophysiology. Current research aims to enhance therapeutic efficacy by combining cell transplantation with exercise interventions, addressing the limitations of cell-transplantation therapy for DMD.</p></div>\",\"PeriodicalId\":36748,\"journal\":{\"name\":\"Current Opinion in Biomedical Engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468451124000035\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468451124000035","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

摘要

杜兴氏肌营养不良症(DMD)是一种遗传性疾病,其特征是因DYSTROPHIN缺乏症相关损伤而导致的重症肌无力。利用骨骼肌干细胞(MuSC)移植进行肌肉再生治疗已显示出巨大前景。经过优化的分化方法产生了高效的诱导多能干细胞衍生的MuSCs(iMuSCs);移植的iMuSCs在DMD小鼠模型中具有很高的再生潜力。然而,仅通过细胞疗法实现 DMD 运动功能的完全病理生理恢复具有挑战性。根据最近的研究,运动可以显著改善 DMD 的病理生理学。目前的研究旨在通过将细胞移植与运动干预相结合来提高疗效,从而解决细胞移植治疗 DMD 的局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell therapy for duchenne muscular dystrophy using induced pluripotent stem cell-derived muscle stem cells and the potential of regenerative rehabilitation

Duchenne muscular dystrophy (DMD) is a hereditary disease characterized by severe muscle weakness resulting from DYSTROPHIN deficiency-associated damage. Muscle regeneration therapy using skeletal muscle stem cell (MuSC) transplantation has demonstrated great promise. Optimized differentiation methods yield efficient induced pluripotent stem cell-derived MuSCs (iMuSCs); transplanted iMuSCs have high regenerative potential in DMD mouse models. However, achieving complete pathophysiological recovery of DMD motor function through cell therapy alone is challenging. According to recent studies, exercise can significantly improve DMD pathophysiology. Current research aims to enhance therapeutic efficacy by combining cell transplantation with exercise interventions, addressing the limitations of cell-transplantation therapy for DMD.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信