Yihui Wang , Wencao Liu , Jianing Zhang , Panpan Geng , Xinchun Jin
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引用次数: 0
摘要
血脑屏障(BBB)损伤是脑内出血(ICH)后的主要病理变化,既是ICH后脑水肿和炎症反应的原因,也是其结果。包括小胶质细胞、周细胞和星形胶质细胞在内的脑免疫细胞(CIC)在 ICH 后 BBB 的损伤和保护中起着至关重要的作用。最近的证据表明,外周免疫细胞(PIC)在 BBB 损伤和保护、脑水肿和神经功能损伤中也发挥着重要作用。因此,调节神经胶质细胞和免疫细胞之间的相互作用有望减轻 ICH 引起的 BBB 损伤。在这篇综述中,我们首先介绍了 CIC、内皮细胞(EC)、少突胶质细胞(OL)和 PIC 在 ICH 后 BBB 损伤和保护中的作用,重点是它们的极化和炎症反应。接下来,我们将具体讨论 ICH 后 CIC 和 PIC 之间的相互影响,如脑-脾轴和脑-肠轴。最后,我们提出神经胶质细胞、PICs 和脑膜淋巴系统可能是缓解 ICH 后 BBB 损伤的潜在靶点,并讨论了通过调节 CICs、ECs 和 PICs 缓解 ICH 后 BBB 损伤的一些分子靶点和潜在策略。
The role of crosstalk between cerebral immune cells and peripheral immune cells in the damage and protection of blood–brain barrier after intracerebral hemorrhage
Blood-brain barrier (BBB) damage is a major pathological change after intracerebral hemorrhage (ICH) and is both the cause and result of brain edema and the inflammatory response post-ICH. Cerebral immune cells (CICs), including microglia, pericytes, and astrocytes play a crucial role in the damage and protection of the BBB after ICH. Recent evidence suggests that peripheral immune cells (PICs) also play an important role in BBB damage and protection, brain edema, and neurological function impairment. Therefore, regulating interactions between glial cells and immune cells is expected to alleviate ICH-induced BBB damage. In this review, we first introduce the role of CICs, endothelial cells (ECs), oligodendrocytes (OLs), and PICs in BBB damage and protection after ICH, focusing on their polarization and inflammatory response. Next, we specifically discuss the crosstalk between CICs and PICs, such as the brain-spleen axis and brain-gut axis after ICH. Finally, we suggest that glial cells, PICs and, meningeal lymphatic system may be potential targets for alleviating BBB damage after ICH, and discuss some molecular targets and potential strategies for alleviating BBB damage after ICH by modulating CICs, ECs, and PICs.