从 4 至 7.9 小时之间抽取的血液中测量的餐后血浆葡萄糖与高血压和心血管疾病死亡率呈正相关关系

Yutang Wang
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引用次数: 0

摘要

根据 4 至 7.9 小时之间的血液测量的餐后血浆葡萄糖(PPG4-7.9h)是否与高血压、糖尿病或心血管疾病(CVD)的死亡率有关,目前尚不清楚。本研究旨在对参加第三次全国健康与营养状况调查的 4896 名美国成年人进行上述关联性研究。研究采用 Cox 比例危险模型来估计 PPG4-7.9h 与死亡率的危险比 (HRs) 和 95% 置信区间 (CIs)。该队列的随访时间为 106,300 人年(平均随访时间为 21.7 年)。在调整了除血红蛋白 A1c(HbA1c)以外的所有测试混杂因素后,PPG4-7.9h 每增加 1 个自然对数单位,高血压(HR,3.50;95% CI,2.34-5.24)、糖尿病(HR,11.7;95% CI,6.85-20.0)和心血管疾病(HR,2.76;95% CI,2.08-3.68)的死亡风险就会增加。进一步调整 HbA1c 后,PPG4-7.9h 仍与高血压(HR,2.15;95% CI,1.13-4.08)和心血管疾病(HR,1.62;95% CI,1.05-2.51)死亡率呈正相关,但与糖尿病死亡率不再相关。亚组分析表明,在既往未确诊心肌梗死或中风的参与者亚组中也得到了类似的结果。总之,PPG4-7.9h 可预测高血压和心血管疾病的死亡率,与 HbA1c 无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Postprandial Plasma Glucose Measured from Blood Taken between 4 and 7.9 h Is Positively Associated with Mortality from Hypertension and Cardiovascular Disease
It is unknown whether postprandial plasma glucose measured from blood taken between 4 and 7.9 h (PPG4–7.9h) is associated with mortality from hypertension, diabetes, or cardiovascular disease (CVD). This study aimed to investigate these associations in 4896 US adults who attended the third National Health and Nutrition Examination Survey. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of PPG4–7.9h for mortality. This cohort was followed up for 106,300 person-years (mean follow-up, 21.7 years). A 1-natural-log-unit increase in PPG4–7.9h was associated with a higher risk of mortality from hypertension (HR, 3.50; 95% CI, 2.34–5.24), diabetes (HR, 11.7; 95% CI, 6.85–20.0), and CVD (HR, 2.76; 95% CI, 2.08–3.68) after adjustment for all the tested confounders except hemoglobin A1c (HbA1c). After further adjustment for HbA1c, PPG4–7.9h remained positively associated with mortality from both hypertension (HR, 2.15; 95% CI, 1.13–4.08) and CVD (HR, 1.62; 95% CI, 1.05–2.51), but was no longer associated with diabetes mortality. Subgroup analyses showed that similar results were obtained in the sub-cohort of participants without a prior diagnosis of myocardial infarction or stroke. In conclusion, PPG4–7.9h predicts mortality from hypertension and CVD, independent of HbA1c.
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