假手术和去肾上腺大鼠腹腔灌洗液中白三烯B4、6-酮-前列腺素F1 α和血栓素B2的测定。

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 1988-09-01

J E Vincent, F J Zijlstra

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引用次数: 0

摘要

在从大鼠腹膜液中分离的巨噬细胞中，激活后，花生四烯酸的代谢物通过环加氧酶和脂加氧酶途径形成。正常动物的细胞主要产生环加氧酶产物。肾上腺切除术后，脂肪加氧酶产物的形成显著增加，而环加氧酶产物的形成较少(1)。在这里描述的实验中，肾上腺切除术对腹膜液中白三烯B4 (LTB4)、6-酮- pgf1 α和血栓素B2 (TxB2)存在的影响被确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Determination of leukotriene B4, 6-keto-prostaglandin F1 alpha and thromboxane B2 in peritoneal lavage fluid of sham-operated and adrenalectomized rats.

In macrophages, isolated from the peritoneal fluid of rats, after activation, formation of metabolites of arachidonic acid occurs both by the cyclooxygenase and lipoxygenase pathways. The cells of normal animals produce mainly cyclooxygenase products. After adrenalectomy, a considerable increase occurs in the formation of lipoxygenase products, and less in those of the cyclooxygenase (1). In the experiments described here, the effect of adrenalectomy on the presence of leukotriene B4 (LTB4), 6-keto-PGF1 alpha and thromboxane B2 (TxB2) in the peritoneal fluid is determined.

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.