纳米结构亚铜金和氧化银复合纳米壳对角膜炎的抗菌效果

IF 2.9 4区 医学 Q1 Medicine
Chen Wang, Yang Liu, Mingchang Zhang
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引用次数: 0

摘要

我们开发了新型无机纳米材料来对抗角膜炎中的耐药细菌感染。这些感染会迅速导致严重的角膜溃疡。由于细菌的耐药性,传统抗生素面临挑战。我们通过设计纳米材料研究了新的疗法。在糖尿病角膜炎动物模型中,我们研究了材料的抗菌特性和机制。在体外,纳米材料显示出很强的抗菌效果,并通过定量分析得到了证实。在体内,我们利用热成像、伤口闭合监测、临床评分和组织病理学证明了纳米材料的抗感染功效。包括体重监测、溶血、生化、血液学分析和器官组织学在内的毒性评估表明,纳米材料对人体或器官没有不良影响。共聚焦显微镜显示,纳米材料结合近红外激光治疗可有效消灭细菌。在治疗浓度下,对红细胞的影响极小。纳米材料,尤其是金-银-氧化亚铜复合纳米壳,对耐药性感染有很强的抵抗力。利用纳米材料和近红外激光进行的光热治疗显示出了良好的前景,不会对正常组织、血液或器官造成伤害。我们的研究结果为角膜炎治疗提供了一种潜在的临床解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibacterial Effect of Nanostructured Cuprous Gold and Silver Oxide Composite Nanoshell on Keratitis
We developed novel inorganic nanomaterials to combat drug-resistant bacterial infections in keratitis. These infections cause rapid severe corneal ulcers. Traditional antibiotics face challenges due to bacterial resistance. We investigated new therapies by designing nanomaterials. In an animal model of diabetic keratitis, we studied the materials’ antibacterial properties and mechanisms. In vitro, nanomaterials displayed strong antibacterial effects, confirmed by quantitative analysis. In vivo, using thermal imaging, wound closure monitoring, clinical scores, and histopathology, we demonstrated nanomaterials’ efficacy against infections. Toxicity evaluations, including weight monitoring, hemolysis, biochemical, hematological analyses, and organ histology, revealed no adverse effects on the body or organs. Confocal microscopy showed effective bacterial eradication using nanomaterials combined with near-infrared laser treatment. Minimal impact on red blood cells was observed at therapeutic concentrations. Nanomaterials, particularly gold-silver-cuprous oxide composite nanoshells, demonstrated potent resistance against drug-resistant infections. Photothermal treatment using nanomaterials and near-infrared laser showed promise without harming normal tissues, blood, or organs. Our findings offer a potential clinical solution for keratitis treatment.
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来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
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