用小剂量口服类固醇成功治疗膀胱内注射卡介苗后的膀胱收缩症

Akinobu Katami, Takamitsu Inoue, Hiromichi Sakurai, M. Onozawa, Shin‐ichi Hisasue, Koji Kawai, Junichi Miyazaki
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引用次数: 0

摘要

膀胱挛缩是膀胱内注射卡介苗的一种罕见不良反应,发生率为 0.2-3.3%。本报告旨在介绍一例使用小剂量口服类固醇成功治疗膀胱挛缩的病例。一名 78 岁的男性接受了第三次经尿道膀胱肿瘤切除术。病理诊断为尿道原位癌。在第五次注射卡介苗杆菌二线诱导疗法后,患者因尿频和持续平均排尿量增加至 80 毫升而中断治疗。根据计算机断层扫描结果和排尿图,患者被诊断为膀胱收缩。在开始口服泼尼松龙(20 毫克/天)后,患者的尿频和 226 毫升的平均排尿量均在 2 周内显著恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Successful treatment with low‐dose oral steroids for contracted bladder after intravesical instillation of Bacillus Calmette–Guérin
Contracted bladder is a rare adverse effect of intravesical Bacillus Calmette–Guérin instillation, with an incidence of 0.2–3.3%. This report aimed to present a case of contracted bladder successfully treated with a low‐dose oral steroid.A 78‐year‐old man underwent a third transurethral resection of a bladder tumor. The pathological diagnosis was urothelial carcinoma in situ. After the fifth instillation of the second‐line induction therapy of Bacillus Calmette–Guérin, the patient discontinued treatment because of increased urinary frequency and a continuous mean voiding volume of 80 mL. The patient was diagnosed with a contracted bladder based on computed tomography findings and a urination chart. After initiating oral prednisolone (20 mg/day), the patient experienced significant recovery within 2 weeks for both urinary frequency and mean voiding volume of 226 mL.A patient with a contracted bladder after Bacillus Calmette–Guérin instillation was successfully treated with low‐dose oral steroid therapy.
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