纳米技术增强了曲酸二棕榈酸酯的化妆品应用,这是一种性能更佳的曲酸衍生物

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Angreni Ayuhastuti, Insan Syah, Sandra Megantara, A. Chaerunisaa
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引用次数: 0

摘要

曲酸(KA)已成为一种突出的酪氨酸酶抑制剂,在化妆品应用方面具有相当大的潜力;然而,它在储存过程中容易出现不稳定性,这对其广泛应用构成了挑战。本综述通过开发各种 KA 衍生物来探讨解决这一局限性的进展,重点关注 C-7 羟基的修饰。为了提高稳定性和功效,人们采用了酯化、形成羟苯基醚、糖基化以及加入氨基酸或三肽衍生物等策略。在这些衍生物中,KA 的棕榈酯衍生物曲酸二棕榈酸酯(KDP)因其在稳定性、渗透性和低毒性方面的显著改善而脱颖而出。最近的发展表明,KDP 在化妆品配方中的应用越来越广泛,目前市场上已有超过 132 种产品,包括各种配方。含有 KDP 的基于纳米技术的配方包括纳米体、纳米乳液、多重乳液、脂质体、固体脂质纳米颗粒(SLN)、乙素体和纳米乳液。此外,KDP 的三项专利和七种先进的系统交付进一步凸显了其重要性。尽管 KDP 越来越普遍,但有关它的文献仍然有限。本综述旨在通过深入探讨 KDP 的合成过程、理化性质、药物制备、在化妆品中的各种应用以及最新的 KDP 纳米技术配方来弥补这一空白。本综述论文旨在探讨 KDP 在化妆品中应用的最新进展。其目的是提高 KA 的稳定性、渗透性并降低其毒性,从而促进这一前景广阔领域的未来研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties
Kojic acid (KA) has emerged as a prominent tyrosinase inhibitor with considerable potential in cosmetic applications; however, its susceptibility to instability during storage poses a challenge to its widespread use. This review explores the advancements in addressing this limitation through the development of various KA derivatives, focusing on the modification of the C-7 hydroxyl group. Strategies such as esterification, hydroxy-phenyl ether formation, glycosylation, and incorporation into amino acid or tripeptide derivatives have been employed to enhance stability and efficacy. Among these derivatives, Kojic Acid Dipalmitate (KDP), a palmitic ester derivative of KA, stands out for its notable improvements in stability, permeability, and low toxicity. Recent developments indicate a growing utilization of KDP in cosmetic formulations, with over 132 available products on the market, encompassing various formulations. Formulations based on nanotechnology, which incorporate KDP, have been provided, including nanosomes, nanocreams, multiple emulsions, liposomes, solid lipid nanoparticles (SLNs), ethosomes, and nanoemulsions. Additionally, three patents and seven advanced system deliveries of KDP further underscore its significance. Despite its increasing prevalence, the literature on KDP remains limited. This review aims to bridge this gap by providing insights into the synthesis process, physicochemical properties, pharmaceutical preparation, diverse applications of KDP in cosmetic products, and recent nanotechnology formulations of KDP. This review paper seeks to explore the recent developments in the use of KDP in cosmetics. The goal is to enhance stability, permeability, and reduce the toxicity of KA, with the intention of promoting future research in this promising sector.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
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