碱性磷酸酶与血脂异常患者心血管疾病的关系:一项为期 6 年的回顾性研究

P. Adamidis, M. Florentin, E. Liberopoulos, A. Koutsogianni, Georgia Anastasiou, G. Liamis, Haralampos Milionis, F. Barkas
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引用次数: 0

摘要

背景和目的:血清碱性磷酸酶(ALP)活性与动脉粥样硬化性心血管疾病(ASCVD)有关。我们旨在研究 ALP 与血脂异常患者 ASCVD 的关系。方法:我们进行了一项回顾性队列研究,研究对象包括希腊约阿尼纳大学综合医院血脂门诊随访≥3年(1999年至2022年)的连续成人血脂异常患者。主要研究终点是在调整了传统风险因素(即性别、年龄、高血压、糖尿病、吸烟和血脂异常)、基线ASCVD和降脂治疗后,基线ALP与ASCVD事件之间的关系。ALP水平按以下三等分进行分层:低:<67 U/L;中:67 U/L;高:<67 U/L;低:<67 U/L:<67 U/L,中:67-79 U/L,高:≥79 U/L。结果:共纳入 1178 名受试者,其中 44% 为男性,中位年龄为 57 岁(范围:49-65 岁)。在为期 6 年的中位随访期间(四分位间距:IQR:4-9),共发生 78 例新的 ASCVD 事件(6.6%)。基线 ALP 水平与 ASCVD 事件之间存在明显的统计学关联(Odds Ratio,OR:6.99;95% Confidence Interval,CI:2.29-21.03,p = 0.001)。与最低三分层的受试者相比,ALP最高三分层的受试者发生ASCVD的几率最高(OR:2.35;95% CI:1.24-4.41,P = 0.008)。结论本研究表明 ALP 与血脂异常患者发生 ASCVD 之间存在关联,这凸显了 ALP 作为预测工具或治疗目标在预防 ASCVD 方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Alkaline Phosphatase with Cardiovascular Disease in Patients with Dyslipidemia: A 6-Year Retrospective Study
Background and Aim: Serum alkaline phosphatase (ALP) activity has been associated with atherosclerotic cardiovascular disease (ASCVD). We aimed to investigate the association of ALP with ASCVD in patients with dyslipidemia. Methods: We conducted a retrospective cohort study including consecutive adults with dyslipidemia followed-up for ≥3 years (from 1999 to 2022) in the outpatient Lipid Clinic of Ioannina University General Hospital, Greece. The primary endpoint was the association between baseline ALP and incident ASCVD after adjusting for traditional risk factors (i.e., sex, age, hypertension, diabetes, smoking, and dyslipidemia), baseline ASCVD, and lipid-lowering treatment. ALP levels were stratified by tertiles as follows: low: <67 U/L, middle: 67–79 U/L, high: ≥79 U/L. Results: Overall, 1178 subjects were included; 44% were males, and their median age was 57 years (range: 49–65). During a 6-year median follow-up (interquartile range: IQR: 4–9), 78 new ASCVD events (6.6%) occurred. A statistically significant association between baseline ALP levels and incident ASCVD was demonstrated (Odds Ratio, OR: 6.99; 95% Confidence Interval, CI: 2.29–21.03, p = 0.001). Subjects in the highest ALP tertile had the highest odds for ASCVD when compared with those in the lowest tertile (OR: 2.35; 95% CI: 1.24–4.41, p = 0.008). Conclusions: The present study indicates an association between ALP and the development of ASCVD in patients with dyslipidemia, which underscores the potential of ALP as a predictive tool or a therapeutic target in the realm of ASCVD prevention within this population.
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