O. N. Ilinskaya, A. G. Galeeva, M. A. Kharitonova, A. I. Kolpakov, M. S. Glukhov, O. N. Lopatin
{"title":"含矿物沸石载体上的益生菌","authors":"O. N. Ilinskaya, A. G. Galeeva, M. A. Kharitonova, A. I. Kolpakov, M. S. Glukhov, O. N. Lopatin","doi":"10.1134/s002626172360372x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">\n<b>Abstract</b>—</h3><p>Probiotic preparations are popular means for restoring the intestinal microbiota; their effectiveness requires long-term preservation of bacteria viability, induction of their proliferation, and manifestation of their functional properties in the body. Carriers of diverse nature are designed to ensure a prolonged release of the probiotic during their transit through the gastrointestinal tract. In the present work, a natural zeolite-containing rock with 25% clinoptilolite, which has sorption, detoxifying, and ion-exchange properties, was used as a carrier. Using transmission microscopy methods, the structure of the carrier was characterized, and the distribution of pores depending on their equivalent diameter was determined. It was shown that the size of the cavities was sufficient for adsorption of bacteria in the macropores and on the surface of the particles. Three <i>Lactobacillus</i> strains loaded onto a carrier and freeze-dried remained viable for 10 months.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Probiotics on a Mineral Zeolite-Containing Carrier\",\"authors\":\"O. N. Ilinskaya, A. G. Galeeva, M. A. Kharitonova, A. I. Kolpakov, M. S. Glukhov, O. N. Lopatin\",\"doi\":\"10.1134/s002626172360372x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">\\n<b>Abstract</b>—</h3><p>Probiotic preparations are popular means for restoring the intestinal microbiota; their effectiveness requires long-term preservation of bacteria viability, induction of their proliferation, and manifestation of their functional properties in the body. Carriers of diverse nature are designed to ensure a prolonged release of the probiotic during their transit through the gastrointestinal tract. In the present work, a natural zeolite-containing rock with 25% clinoptilolite, which has sorption, detoxifying, and ion-exchange properties, was used as a carrier. Using transmission microscopy methods, the structure of the carrier was characterized, and the distribution of pores depending on their equivalent diameter was determined. It was shown that the size of the cavities was sufficient for adsorption of bacteria in the macropores and on the surface of the particles. Three <i>Lactobacillus</i> strains loaded onto a carrier and freeze-dried remained viable for 10 months.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-02-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1134/s002626172360372x\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s002626172360372x","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Probiotics on a Mineral Zeolite-Containing Carrier
Abstract—
Probiotic preparations are popular means for restoring the intestinal microbiota; their effectiveness requires long-term preservation of bacteria viability, induction of their proliferation, and manifestation of their functional properties in the body. Carriers of diverse nature are designed to ensure a prolonged release of the probiotic during their transit through the gastrointestinal tract. In the present work, a natural zeolite-containing rock with 25% clinoptilolite, which has sorption, detoxifying, and ion-exchange properties, was used as a carrier. Using transmission microscopy methods, the structure of the carrier was characterized, and the distribution of pores depending on their equivalent diameter was determined. It was shown that the size of the cavities was sufficient for adsorption of bacteria in the macropores and on the surface of the particles. Three Lactobacillus strains loaded onto a carrier and freeze-dried remained viable for 10 months.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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