Hanui Jo, Lipjung Jung, Nuri Kim, Gi-Wook Kim, Dongwon Lee
{"title":"用于治疗急性肝损伤的胆汁酸基多药纳米粒子","authors":"Hanui Jo, Lipjung Jung, Nuri Kim, Gi-Wook Kim, Dongwon Lee","doi":"10.1007/s13233-023-00241-7","DOIUrl":null,"url":null,"abstract":"<div><p>Acute liver failure and non-alcoholic fatty liver disease (NAFLD) are a common chronic liver disease worldwide, causing tremendous clinical burden. Despite the increasing prevalence of these life-threatening liver damages, effective medical treatment has not been established. Here, we developed a new treatment strategy based on ursodeoxycholic acid (UDCA) which is one of bile acids and effective for the liver diseases. We designed poly(ursodeoxycholic acid-oxalate) (PUOX) as a polymer prodrug of UDCA. PUOX has hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-scavenging peroxalate ester bonds and could be formulated into nanoparticles. PUOX nanoparticles released UDCA in a H<sub>2</sub>O<sub>2</sub>-triggered manner and exerted concurrent antioxidant and anti-inflammatory effects with cytoprotective actions. In mouse models of acute liver failure and NAFLD, PUOX nanoparticles exerted highly potent therapeutic effects without noticeable toxicity. PUOX nanoparticles could be a promising approach to improve the efficacy for various H<sub>2</sub>O<sub>2</sub>-associated liver disease.</p><h3>Graphical abstract</h3><p>Poly(ursodeoxycholic acid-oxalate) (PUOX) is a H<sub>2</sub>O<sub>2</sub>-responsive polymeric prodrug of UDCA. PUOX nanoparticles exert potent cytoprotective effects in liver diseases such as fatty acid and drug-intoxicated acute liver failure.\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 5","pages":"415 - 426"},"PeriodicalIF":2.8000,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bile acid-based polydrug nanoparticles for the treatment of acute liver injury\",\"authors\":\"Hanui Jo, Lipjung Jung, Nuri Kim, Gi-Wook Kim, Dongwon Lee\",\"doi\":\"10.1007/s13233-023-00241-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Acute liver failure and non-alcoholic fatty liver disease (NAFLD) are a common chronic liver disease worldwide, causing tremendous clinical burden. Despite the increasing prevalence of these life-threatening liver damages, effective medical treatment has not been established. Here, we developed a new treatment strategy based on ursodeoxycholic acid (UDCA) which is one of bile acids and effective for the liver diseases. We designed poly(ursodeoxycholic acid-oxalate) (PUOX) as a polymer prodrug of UDCA. PUOX has hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-scavenging peroxalate ester bonds and could be formulated into nanoparticles. PUOX nanoparticles released UDCA in a H<sub>2</sub>O<sub>2</sub>-triggered manner and exerted concurrent antioxidant and anti-inflammatory effects with cytoprotective actions. In mouse models of acute liver failure and NAFLD, PUOX nanoparticles exerted highly potent therapeutic effects without noticeable toxicity. PUOX nanoparticles could be a promising approach to improve the efficacy for various H<sub>2</sub>O<sub>2</sub>-associated liver disease.</p><h3>Graphical abstract</h3><p>Poly(ursodeoxycholic acid-oxalate) (PUOX) is a H<sub>2</sub>O<sub>2</sub>-responsive polymeric prodrug of UDCA. PUOX nanoparticles exert potent cytoprotective effects in liver diseases such as fatty acid and drug-intoxicated acute liver failure.\\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":688,\"journal\":{\"name\":\"Macromolecular Research\",\"volume\":\"32 5\",\"pages\":\"415 - 426\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-02-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Macromolecular Research\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13233-023-00241-7\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular Research","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s13233-023-00241-7","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Bile acid-based polydrug nanoparticles for the treatment of acute liver injury
Acute liver failure and non-alcoholic fatty liver disease (NAFLD) are a common chronic liver disease worldwide, causing tremendous clinical burden. Despite the increasing prevalence of these life-threatening liver damages, effective medical treatment has not been established. Here, we developed a new treatment strategy based on ursodeoxycholic acid (UDCA) which is one of bile acids and effective for the liver diseases. We designed poly(ursodeoxycholic acid-oxalate) (PUOX) as a polymer prodrug of UDCA. PUOX has hydrogen peroxide (H2O2)-scavenging peroxalate ester bonds and could be formulated into nanoparticles. PUOX nanoparticles released UDCA in a H2O2-triggered manner and exerted concurrent antioxidant and anti-inflammatory effects with cytoprotective actions. In mouse models of acute liver failure and NAFLD, PUOX nanoparticles exerted highly potent therapeutic effects without noticeable toxicity. PUOX nanoparticles could be a promising approach to improve the efficacy for various H2O2-associated liver disease.
Graphical abstract
Poly(ursodeoxycholic acid-oxalate) (PUOX) is a H2O2-responsive polymeric prodrug of UDCA. PUOX nanoparticles exert potent cytoprotective effects in liver diseases such as fatty acid and drug-intoxicated acute liver failure.
期刊介绍：
Original research on all aspects of polymer science, engineering and technology, including nanotechnology
Presents original research articles on all aspects of polymer science, engineering and technology
Coverage extends to such topics as nanotechnology, biotechnology and information technology
The English-language journal of the Polymer Society of Korea
Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
