Ekta Bala, Varun Aggarwal, Pawan Kumar, Rohit Sharma, Saima, Manickam Selvaraj, Mohammed A. Assiri, Praveen Kumar Verma
{"title":"作为生物活性剂潜在生物资源的五种喜马拉雅杂草:从有毒化合物到有价值的支架","authors":"Ekta Bala, Varun Aggarwal, Pawan Kumar, Rohit Sharma, Saima, Manickam Selvaraj, Mohammed A. Assiri, Praveen Kumar Verma","doi":"10.1007/s11101-024-09921-3","DOIUrl":null,"url":null,"abstract":"<div><p>Natural products are highly prevalent in Himalayan region clustered in medicinal and aromatic plants including weeds. Toxic weed plants are of serious concerns due to their hazardous effects to humans, environment, and animals. The cause of toxicity of these toxic weed plants is due to the presence of toxic secondary metabolites. Several toxic secondary metabolites have been reported and characterised in these weed plants. There are several functionalities (toxicophores) in these secondary metabolites which have been identified responsible for the toxic effects of these naturally occurring molecules. The eradication of these toxic weed plants is the major strategy to minimize the hazardous effects. Albeit, there are possibilities for the utilization of these abundantly available toxic secondary metabolites as the valuable scaffolds by their synthetic modification to alter their toxicophores. Herein, we have compiled the reports based on the synthetic modification of the toxicophores present in these secondary metabolites and evaluated for their various pharmacological potential. Several molecules have been illustrated which are present in good amount in the toxic weeds and utilised as valuable bioactive scaffolds through intervention of synthetic modifications. The current review will be highly beneficial for the future developments utilising the abundantly available toxic molecules isolated from toxic weed plants and will also provide the alternative and effective strategy for the utilization of these toxic weeds.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.3000,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Five Himalayan weeds as potential bioresources for bioactive agents: toxic compounds to valuable scaffolds\",\"authors\":\"Ekta Bala, Varun Aggarwal, Pawan Kumar, Rohit Sharma, Saima, Manickam Selvaraj, Mohammed A. Assiri, Praveen Kumar Verma\",\"doi\":\"10.1007/s11101-024-09921-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Natural products are highly prevalent in Himalayan region clustered in medicinal and aromatic plants including weeds. Toxic weed plants are of serious concerns due to their hazardous effects to humans, environment, and animals. The cause of toxicity of these toxic weed plants is due to the presence of toxic secondary metabolites. Several toxic secondary metabolites have been reported and characterised in these weed plants. There are several functionalities (toxicophores) in these secondary metabolites which have been identified responsible for the toxic effects of these naturally occurring molecules. The eradication of these toxic weed plants is the major strategy to minimize the hazardous effects. Albeit, there are possibilities for the utilization of these abundantly available toxic secondary metabolites as the valuable scaffolds by their synthetic modification to alter their toxicophores. Herein, we have compiled the reports based on the synthetic modification of the toxicophores present in these secondary metabolites and evaluated for their various pharmacological potential. Several molecules have been illustrated which are present in good amount in the toxic weeds and utilised as valuable bioactive scaffolds through intervention of synthetic modifications. The current review will be highly beneficial for the future developments utilising the abundantly available toxic molecules isolated from toxic weed plants and will also provide the alternative and effective strategy for the utilization of these toxic weeds.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":733,\"journal\":{\"name\":\"Phytochemistry Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2024-02-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Reviews\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11101-024-09921-3\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Reviews","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s11101-024-09921-3","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
Five Himalayan weeds as potential bioresources for bioactive agents: toxic compounds to valuable scaffolds
Natural products are highly prevalent in Himalayan region clustered in medicinal and aromatic plants including weeds. Toxic weed plants are of serious concerns due to their hazardous effects to humans, environment, and animals. The cause of toxicity of these toxic weed plants is due to the presence of toxic secondary metabolites. Several toxic secondary metabolites have been reported and characterised in these weed plants. There are several functionalities (toxicophores) in these secondary metabolites which have been identified responsible for the toxic effects of these naturally occurring molecules. The eradication of these toxic weed plants is the major strategy to minimize the hazardous effects. Albeit, there are possibilities for the utilization of these abundantly available toxic secondary metabolites as the valuable scaffolds by their synthetic modification to alter their toxicophores. Herein, we have compiled the reports based on the synthetic modification of the toxicophores present in these secondary metabolites and evaluated for their various pharmacological potential. Several molecules have been illustrated which are present in good amount in the toxic weeds and utilised as valuable bioactive scaffolds through intervention of synthetic modifications. The current review will be highly beneficial for the future developments utilising the abundantly available toxic molecules isolated from toxic weed plants and will also provide the alternative and effective strategy for the utilization of these toxic weeds.
期刊介绍:
Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.