用于水介质中寡糖传感的荧光团-葡聚糖共轭物

IF 2.3 4区化学 Q3 POLYMER SCIENCE

Polymer Journal Pub Date : 2024-02-07 DOI:10.1038/s41428-024-00889-7

Hiroki Kurohara, Yumiko Hori, Munenori Numata, Gaku Fukuhara

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引用次数: 0

摘要

利用传统超分子方法感知水介质中糖类的能力是现代化学的一个转折点。在这里，我们利用荧光团修饰的支链葡聚糖实现了寡糖传感。通过新开发的基于葡聚糖的化学传感器，我们以选择性和灵敏的方式实现了对阿卡波糖的感测。对化学传感器的光学性质和形态变化进行了研究，揭示了球状到聚集过程在寡糖传感中起着关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Fluorophore-glucan conjugate for oligosaccharide sensing in aqueous media

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Fluorophore-glucan conjugate for oligosaccharide sensing in aqueous media

The ability to sense saccharides in aqueous media using conventional supramolecular approaches was a turning point in modern chemistry. Herein, we performed oligosaccharide sensing using fluorophore-modified branched glucans. Through the newly developed glucan-based chemosensor, acarbose sensing was achieved in a selectively and sensitive manner. The optical properties and morphological changes in the chemosensor were investigated, revealing that the globule-to-coaggregation process plays a key role in oligosaccharide sensing. The fluorophore-modified glucan, TPE-6BG3 adopts an extended, random-coiled form in DMSO, which does not fluoresce. The morphology of the TPE-6BG3 chemosensor changes drastically to a dynamic globule in aqueous media. The dynamic, “induced-fit” globule selectively and sensitively recognizes the medicinally-useful tetrasaccharide, acarbose via glucan-saccharide coaggregation.

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来源期刊

Polymer Journal 化学-高分子科学

CiteScore

5.60

自引率

7.10%

发文量

131

审稿时长

2.5 months

期刊介绍： Polymer Journal promotes research from all aspects of polymer science from anywhere in the world and aims to provide an integrated platform for scientific communication that assists the advancement of polymer science and related fields. The journal publishes Original Articles, Notes, Short Communications and Reviews. Subject areas and topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Polymer synthesis and reactions Polymer structures Physical properties of polymers Polymer surface and interfaces Functional polymers Supramolecular polymers Self-assembled materials Biopolymers and bio-related polymer materials Polymer engineering.