2021-2022 年韩国野生鸟类中高致病性甲型禽流感（H5N1）病毒的基因组流行病学：病毒流行模式的变化

IF 5.5 2区医学 Q1 VIROLOGY

Virus Evolution Pub Date : 2024-02-12 DOI:10.1093/ve/veae014

Ji-Yun Kim, Sol Jeong, Da-Won Kim, Dong-Wook Lee, Dong-Hun Lee, Daehun Kim, Jung-Hoon Kwon

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引用次数: 0

摘要

自2016年以来，世界各地的野鸟中都检测到了2.3.4.4b支系高致病性甲型禽流感（HPAI）病毒，并引起了反复爆发。2021-2022 年冬季，我们在韩国的野鸟中检测到 1 种 H5N8 和 43 种 H5N1 2.3.4.4b 支系高致病性禽流感病毒。系统进化分析表明，H5N1 病毒的 HA 基因被分为两个不同的基因组（N1.G1 和 N1.G2）。贝叶斯系统动力学分析表明，野生鸟类在病毒传播和长期维持中扮演着重要角色。我们发现五个基因型（N1.G1.1、N1.G2、N1.G2.1、N1.G2.2 和 N1.G2.2.1）具有不同的基因片段组合，很可能是由低致病性禽流感病毒重组而成。我们的研究结果表明，与以往的 H5 高致病性禽流感病毒支系相比，2.3.4.4b 支系可在野禽中长期存活，并导致持续爆发。我们的研究强调有必要加强控制措施，以应对不断变化的病毒流行病学。

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Genomic Epidemiology of Highly Pathogenic Avian Influenza A (H5N1) Virus in Wild Birds in South Korea during 2021–2022: Changes in Viral Epidemic Patterns

Clade 2.3.4.4b highly pathogenic avian influenza A (HPAI) viruses have been detected in wild birds worldwide, causing recurrent outbreaks since 2016. During the winter of 2021–2022, we detected 1 H5N8 and 43 H5N1 clade 2.3.4.4b HPAI viruses from wild birds in South Korea. Phylogenetic analysis revealed that HA gene of H5N1 viruses was divided into two genetically distinct groups (N1.G1 and N1.G2). Bayesian phylodynamic analysis demonstrated that wild birds play a vital role in viral transmission and long-term maintenance. We identified five genotypes (N1.G1.1, N1.G2, N1.G2.1, N1.G2.2, and N1.G2.2.1) having distinct gene segment constellations most probably produced by reassortments with low-pathogenic avian influenza viruses. Our results suggest that clade 2.3.4.4b persists in wild birds for a long time, causing continuous outbreaks, compared with previous clades of H5 HPAI viruses. Our study emphasizes the need for enhancing control measures in response to the changing viral epidemiology.

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来源期刊

Virus Evolution Immunology and Microbiology-Microbiology

CiteScore

10.50

自引率

5.70%

发文量

108

审稿时长

14 weeks

期刊介绍： Virus Evolution is a new Open Access journal focusing on the long-term evolution of viruses, viruses as a model system for studying evolutionary processes, viral molecular epidemiology and environmental virology. The aim of the journal is to provide a forum for original research papers, reviews, commentaries and a venue for in-depth discussion on the topics relevant to virus evolution.