高恐惧状态有助于腹侧海马参与杏仁核基底外侧神经元的活动

IF 2.6 3区 医学 Q2 BEHAVIORAL SCIENCES
Alexandra C. Ritger, Rachel K. Parker, Sydney Trask, Nicole C. Ferrara
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引用次数: 0

摘要

恐惧记忆的形成和保持依赖于分布式神经回路的激活。尤其是杏仁基底外侧(BLA)和海马腹侧(VH),它们是支持情境性恐惧记忆过程的两个区域,并且共享相互联系。VH → BLA 通路对于初始学习后恐惧感的增加至关重要,无论是在消退学习后恐惧感的恢复过程中,还是在恐惧泛化过程中都是如此。这就提出了一种可能性,即 VH 投射到 BLA 的功能变化支持学习到的恐惧的增加。与此相一致的是,恐惧也可以通过重新巩固改变记忆的原始内容而增加,如在恐惧提升过程中。然而,人们对支持与再巩固相关的恐惧增加的 VH → BLA 通路的功能变化知之甚少。在这项研究中,我们利用体内细胞外电生理学研究了恐惧升高和标准恐惧检索程序导致的BLA和VH → BLA通路的神经元功能变化。与标准恐惧检索条件相比,恐惧表达的升高伴随着更高的BLA自发发射。在不同的刺激频率下,我们还发现与标准恐惧检索相比,VH 刺激在恐惧升高后会诱发更高的 BLA 发射。这些结果表明,恐惧升高与 VH 驱动 BLA 神经元活动的能力增强有关,突出了一个参与强化现有恐惧记忆的潜在回路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Elevated fear states facilitate ventral hippocampal engagement of basolateral amygdala neuronal activity
Fear memory formation and retention rely on the activation of distributed neural circuits. The basolateral amygdala (BLA) and ventral hippocampus (VH) in particular are two regions that support contextual fear memory processes and share reciprocal connections. The VH → BLA pathway is critical for increases in fear after initial learning, in both fear renewal following extinction learning and during fear generalization. This raises the possibility that functional changes in VH projections to the BLA support increases in learned fear. In line with this, fear can also be increased with alterations to the original content of the memory via reconsolidation, as in fear elevation procedures. However, very little is known about the functional changes in the VH → BLA pathway supporting reconsolidation-related increases in fear. In this study, we used in vivo extracellular electrophysiology to examine the functional neuronal changes within the BLA and in the VH → BLA pathway as a result of fear elevation and standard fear retrieval procedures. Elevated fear expression was accompanied by higher BLA spontaneous firing compared to a standard fear retrieval condition. Across a range of stimulation frequencies, we also found that VH stimulation evoked higher BLA firing following fear elevation compared to standard retrieval. These results suggest that fear elevation is associated with an increased capacity of the VH to drive neuronal activity in the BLA, highlighting a potential circuit involved in strengthening existing fear memories.
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来源期刊
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
4.70
自引率
3.30%
发文量
506
审稿时长
6-12 weeks
期刊介绍: Frontiers in Behavioral Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the neural mechanisms underlying behavior. Field Chief Editor Nuno Sousa at the Instituto de Pesquisa em Ciências da Vida e da Saúde (ICVS) is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. This journal publishes major insights into the neural mechanisms of animal and human behavior, and welcomes articles studying the interplay between behavior and its neurobiological basis at all levels: from molecular biology and genetics, to morphological, biochemical, neurochemical, electrophysiological, neuroendocrine, pharmacological, and neuroimaging studies.
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