延迟贴现率与焦虑症症状和诊断的关系

Caroline H. Armstrong, Elizabeth A. Hoge
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摘要

延迟折现是指随着获得奖励的时间增加,个人对奖励的价值产生贬值的倾向。延迟折现率描述了一个人在多大程度上更喜欢立即获得的较小奖励,而不是延迟获得的较大奖励。折现率因人而异,有学者认为,异常折现率可能代表一种跨诊断过程,与多种精神疾病有关。然而,关于折扣率与焦虑症状和正式诊断的焦虑症之间的关系,还需要进一步的研究。因此,本研究以异质性焦虑症患者和健康对照者为样本,研究了货币贴现率与焦虑症状维度测量以及广泛性焦虑症(GAD)、社交焦虑症(SAD)和惊恐障碍(PD)诊断之间的关系。此外,我们还研究了折扣率与生理惊吓反应(即恐惧强化和焦虑强化惊吓)的关系。从2019年到2022年,被正式诊断为GAD、SAD和/或PD的成年人(89人)和健康对照组(66人)完成了焦虑症状的维度测量;一项假定的货币延迟折现任务,该任务遵循调整滴定程序;以及中性、可预测和不可预测(NPU)威胁测试。相关分析表明,贴现率与焦虑的任何维度测量均无显著相关性(ps ≥ .31);控制适当协变量的逻辑回归表明,贴现率与任何焦虑症诊断均无显著相关性(ps ≥ .14)。此外,折现率与任何生理惊吓测量值也无明显相关性(ps ≥ .22)。我们确实发现,在大流行期间完成延迟折现任务与较浅(较低)的折现率明显相关。总之,研究结果表明,货币延迟贴现范式在焦虑症领域可能并不是一个非常有用的工具,而且异常贴现率的潜在跨诊断作用,至少是通过货币贴现范式测量的异常贴现率,可能不会扩展到焦虑症。不过,鉴于样本量相对较小等局限性,对结果的解释应谨慎,因为样本量相对较小,无法提供足够的统计能力来检测小规模的效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of Delay Discounting Rate with Anxiety Disorder Symptomatology and Diagnoses

Delay discounting is the tendency for individuals to devalue a reward as time to receipt of the reward increases. Rates of delay discounting describe to what extent one prefers smaller rewards delivered immediately over larger rewards delivered at a delay. Discount rates vary among individuals, and authors have suggested that abnormal discount rate may represent a transdiagnostic process implicated in multiple psychiatric disorders. However, further research is needed on how discount rate may relate to anxiety symptomatology and formally diagnosed anxiety disorders. Thus, the present study, in a sample of individuals with heterogeneous anxiety disorders and healthy controls, examined how monetary discount rate related to dimensional measures of anxiety symptomatology as well as diagnoses of generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder (PD). In addition, we examined how discount rate related to physiological startle response (i.e., fear-potentiated and anxiety-potentiated startle). From 2019 to 2022, adults with a formal diagnosis of GAD, SAD, and/or PD (N = 89) and healthy controls (N = 66) completed dimensional measures of anxiety symptomatology; a hypothetical monetary delay discounting task that followed an adjusting titration procedure; and the neutral, predictable, and unpredictable (NPU) threat test. Correlational analyses revealed that discount rate was not significantly associated with any dimensional measure of anxiety (ps ≥ .31); logistic regressions controlling for appropriate covariates indicated that discount rate was not significantly associated with any anxiety disorder diagnosis (ps ≥ .14). In addition, discount rate was not significantly correlated with any measure of physiological startle (ps ≥ .22). We did find that completion of the delay discounting task during the pandemic was significantly associated with shallower (lower) discount rate. Overall, results suggest that monetary delay discounting paradigms might not represent a highly useful tool within the anxiety disorders field in particular, and the potential transdiagnostic role of abnormal discount rate, at least as measured with monetary discounting paradigms, might not extend to anxiety disorders. However, results should be interpreted cautiously given limitations such as the relatively small sample size, which precluded adequate statistical power to detect effects of small sizes.

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