藻酸盐-结冷胶和藻酸盐-黄原胶微珠持续释放阿昔洛韦

Q3 Materials Science
Sudipta Das , Arnab Samanta , Sawan Das , Amit Kumar Nayak
{"title":"藻酸盐-结冷胶和藻酸盐-黄原胶微珠持续释放阿昔洛韦","authors":"Sudipta Das ,&nbsp;Arnab Samanta ,&nbsp;Sawan Das ,&nbsp;Amit Kumar Nayak","doi":"10.1016/j.jciso.2024.100106","DOIUrl":null,"url":null,"abstract":"<div><p>In the current research, acyclovir-loaded microbeads were formulated via ionotropic gelation using sodium alginate-gellan gum and sodium alginate-xanthan gum. In the preparation of these acyclovir-loaded microbeads, aluminium chloride and barium chloride were used as cross-linking agents. All these ionotropically-gelled acyclovir-loaded alginate-gellan gum microbeads and alginate-xanthan gum microbeads exhibited good percent yields (85.07 ± 1.58 to 92.17 ± 3.02%) and drug entrapment efficiencies (74.09 ± 1.38 to 95.16 ± 3.37%). Acyclovir-loaded alginate-gellan gum microbeads exhibited comparatively smaller average particle sizes (0.54 ± 0.02 to 0.71 ± 0.03 mm) than those of acyclovir-loaded alginate-xanthan gum microbeads (0.60 ± 0.02 to 0.82 ± 0.04 mm). Acyclovir-loaded alginate-xanthan gum microbeads exhibited comparatively higher swelling than that of acyclovir-loaded alginate-gellan gum microbeads. A sustained pattern of acyclovir release over 240 min was noticed by these microbeads. Surface morphology analysis of the best microbeads formulation (on the basis of sustained acyclovir release data) was done by scanning electron microscopy (SEM). These kinds of ionotropically-gelled alginate-based microbeads might be advantageous to facilitate enhanced patient compliances with minimal dosing frequency and enhanced oral bioavailability.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000059/pdfft?md5=e099090f47f9871527ed8cb5b5e885c8&pid=1-s2.0-S2666934X24000059-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Sustained release of acyclovir from alginate-gellan gum and alginate-xanthan gum microbeads\",\"authors\":\"Sudipta Das ,&nbsp;Arnab Samanta ,&nbsp;Sawan Das ,&nbsp;Amit Kumar Nayak\",\"doi\":\"10.1016/j.jciso.2024.100106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In the current research, acyclovir-loaded microbeads were formulated via ionotropic gelation using sodium alginate-gellan gum and sodium alginate-xanthan gum. In the preparation of these acyclovir-loaded microbeads, aluminium chloride and barium chloride were used as cross-linking agents. All these ionotropically-gelled acyclovir-loaded alginate-gellan gum microbeads and alginate-xanthan gum microbeads exhibited good percent yields (85.07 ± 1.58 to 92.17 ± 3.02%) and drug entrapment efficiencies (74.09 ± 1.38 to 95.16 ± 3.37%). Acyclovir-loaded alginate-gellan gum microbeads exhibited comparatively smaller average particle sizes (0.54 ± 0.02 to 0.71 ± 0.03 mm) than those of acyclovir-loaded alginate-xanthan gum microbeads (0.60 ± 0.02 to 0.82 ± 0.04 mm). Acyclovir-loaded alginate-xanthan gum microbeads exhibited comparatively higher swelling than that of acyclovir-loaded alginate-gellan gum microbeads. A sustained pattern of acyclovir release over 240 min was noticed by these microbeads. Surface morphology analysis of the best microbeads formulation (on the basis of sustained acyclovir release data) was done by scanning electron microscopy (SEM). These kinds of ionotropically-gelled alginate-based microbeads might be advantageous to facilitate enhanced patient compliances with minimal dosing frequency and enhanced oral bioavailability.</p></div>\",\"PeriodicalId\":73541,\"journal\":{\"name\":\"JCIS open\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666934X24000059/pdfft?md5=e099090f47f9871527ed8cb5b5e885c8&pid=1-s2.0-S2666934X24000059-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JCIS open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666934X24000059\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Materials Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JCIS open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666934X24000059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Materials Science","Score":null,"Total":0}
引用次数: 0

摘要

在目前的研究中,使用海藻酸钠-结冷胶和海藻酸钠-黄原胶,通过离子凝胶法配制了阿昔洛韦负载微珠。在制备这些阿昔洛韦微珠时,使用了氯化铝和氯化钡作为交联剂。所有这些离子胶化的阿昔洛韦负载海藻酸盐-结冷胶微珠和海藻酸盐-黄原胶微珠都表现出良好的产率(85.07 ± 1.58 至 92.17 ± 3.02%)和药物包埋效率(74.09 ± 1.38 至 95.16 ± 3.37%)。与负载阿昔洛韦的海藻酸-黄原胶微珠(0.60 ± 0.02 至 0.82 ± 0.04 mm)相比,负载阿昔洛韦的海藻酸-黄原胶微珠的平均粒径较小(0.54 ± 0.02 至 0.71 ± 0.03 mm)。与负载阿昔洛韦的海藻酸盐-黄原胶微珠相比,负载阿昔洛韦的海藻酸盐-结冷胶微珠表现出更高的膨胀率。这些微珠在 240 分钟内持续释放阿昔洛韦。利用扫描电子显微镜(SEM)对最佳微珠配方(根据阿昔洛韦的持续释放数据)进行了表面形态分析。这些基于藻酸盐的离子态胶化微珠可能有助于提高患者的依从性,减少给药次数,提高口服生物利用度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sustained release of acyclovir from alginate-gellan gum and alginate-xanthan gum microbeads

Sustained release of acyclovir from alginate-gellan gum and alginate-xanthan gum microbeads

In the current research, acyclovir-loaded microbeads were formulated via ionotropic gelation using sodium alginate-gellan gum and sodium alginate-xanthan gum. In the preparation of these acyclovir-loaded microbeads, aluminium chloride and barium chloride were used as cross-linking agents. All these ionotropically-gelled acyclovir-loaded alginate-gellan gum microbeads and alginate-xanthan gum microbeads exhibited good percent yields (85.07 ± 1.58 to 92.17 ± 3.02%) and drug entrapment efficiencies (74.09 ± 1.38 to 95.16 ± 3.37%). Acyclovir-loaded alginate-gellan gum microbeads exhibited comparatively smaller average particle sizes (0.54 ± 0.02 to 0.71 ± 0.03 mm) than those of acyclovir-loaded alginate-xanthan gum microbeads (0.60 ± 0.02 to 0.82 ± 0.04 mm). Acyclovir-loaded alginate-xanthan gum microbeads exhibited comparatively higher swelling than that of acyclovir-loaded alginate-gellan gum microbeads. A sustained pattern of acyclovir release over 240 min was noticed by these microbeads. Surface morphology analysis of the best microbeads formulation (on the basis of sustained acyclovir release data) was done by scanning electron microscopy (SEM). These kinds of ionotropically-gelled alginate-based microbeads might be advantageous to facilitate enhanced patient compliances with minimal dosing frequency and enhanced oral bioavailability.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
JCIS open
JCIS open Physical and Theoretical Chemistry, Colloid and Surface Chemistry, Surfaces, Coatings and Films
CiteScore
4.10
自引率
0.00%
发文量
0
审稿时长
36 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信