细菌的多层基因组防御系统

IF 5.9 2区生物学 Q1 MICROBIOLOGY

Current opinion in microbiology Pub Date : 2024-02-17 DOI:10.1016/j.mib.2024.102436

Aleksei Agapov , Kate S Baker , Paritosh Bedekar , Rama P Bhatia , Tim R Blower , Michael A Brockhurst , Cooper Brown , Charlotte E Chong , Joanne L Fothergill , Shirley Graham , James PJ Hall , Alice Maestri , Stuart McQuarrie , Anna Olina , Stefano Pagliara , Mario Recker , Anna Richmond , Steven J Shaw , Mark D Szczelkun , Tiffany B Taylor , Rosanna Wright

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引用次数: 0

摘要

细菌已经进化出多种防御机制来抵御移动遗传因子，包括限制性修饰系统和 CRISPR-Cas。近年来，人们发现了数十种以前未知的防御系统（DSs）。值得注意的是，不同的防御系统往往共存于同一基因组中，有些防御系统的共存频率远远高于偶然的预期，这意味着可能存在协同作用。最近的研究提供了防御机制相互增强或互补的证据。在此，我们将从机制、调控、生态和进化等层面回顾 DSs 之间的相互作用。

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Multi-layered genome defences in bacteria

Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

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来源期刊

Current opinion in microbiology 生物-微生物学

CiteScore

10.00

自引率

0.00%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Host-microbe interactions: bacteria Cell regulation Environmental microbiology Host-microbe interactions: fungi/parasites/viruses Antimicrobials Microbial systems biology Growth and development: eukaryotes/prokaryotes