根据结肠位置和疾病活动性分类的溃疡性结肠炎患者粘膜渗透性的差异。

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2024-05-01 DOI:10.14309/ctg.0000000000000692

Wataru Shiratori, Yuki Ohta, Keisuke Matsusaka, Yuhei Ohyama, Yukiyo Mamiya, Hayato Nakazawa, Satsuki Takahashi, Ryosuke Horio, Chihiro Goto, Michiko Sonoda, Akane Kurosugi, Tatsuya Kaneko, Naoki Akizue, Hideaki Ishigami, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Tomoaki Matsumura, Yuki Shiko, Yoshihito Ozawa, Jun Kato, Junichiro Ikeda, Naoya Kato

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引用次数: 0

摘要

背景：S：影响溃疡性结肠炎（UC）黏膜通透性（MP）的因素在很大程度上尚属未知。我们的目的是研究根据结肠位置分类的 UC 患者之间的 MP 差异，并评估局部 MP 与 UC 的内镜或组织学活动之间的相关性：方法：使用乌星室测量 UC 患者和健康人（HI）的升结肠、降结肠和直肠粘膜组织样本的经上皮电阻（TER），TER 与通透性成反比。对 UC 患者和 HI 患者的 TER 进行比较，并根据 UC 的结肠位置和疾病活动性进行评估：本研究共纳入 38 名 UC 患者和 12 名 HI 患者。在 HI 和 UC 患者中，肛门一侧的 MP 往往较高。UC 患者升结肠的 TER 明显低于 HI（45.3 ± 9.0 Ω × cm2 vs. 53.5 ± 9.7 Ω × cm2，p = 0.01）。UC 的通透性增加也出现在降结肠，但仅限于炎症累及该部位时。仅在直肠发现 TER 与内窥镜活动之间存在明显相关性（r = -0.49，p = 0.002）。TER与UC组织学无明显相关性：结肠中的 MP 因结肠位置而异。UC 患者升结肠的 MP 出现了疾病特异性变化，而直肠的 MP 与内镜活动成正比增加。

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Differences in Mucosal Permeability Among Patients With Ulcerative Colitis Classified Based on the Colonic Location and Disease Activity.

Introduction: Factors affecting mucosal permeability (MP) in ulcerative colitis (UC) are largely unknown. We aimed to investigate the difference in MP among patients with UC classified according to the colonic locations and to evaluate the correlations between local MP and endoscopic or histological activity of UC.

Methods: The transepithelial electrical resistance (TER), which is inversely proportional to permeability, of tissue samples from the mucosa of the ascending colon, descending colon, and rectum of patients with UC and healthy individuals (HIs) was measured by using the Ussing chamber. TERs were compared between patients with UC and HIs and evaluated according to colonic locations and disease activity of UC.

Results: Thirty-eight patients with UC and 12 HIs were included in this study. Both in HIs and patients with UC, MP tends to be higher in the anal side. TER in the ascending colon was significantly lower in patients with UC than in HIs (45.3 ± 9.0 Ω × cm 2 vs 53.5 ± 9.7 Ω × cm 2 , P = 0.01). The increased permeability in UC was observed also in the descending colon, only when the inflammation involved the location. A significant correlation between TER and endoscopic activity was found in the rectum only ( r = -0.49, P = 0.002). There were no significant correlations between TERs and UC histology.

Discussion: The MP in the colon differs according to the colonic location. The ascending colon among patients with UC showed disease-specific changes in MP, whereas the MP is increased in proportion to the endoscopic activity in the rectum.

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.