Francesco Cairo, Raffaele Cavalcanti, Luigi Barbato, Michele Nieri, Walter Castelluzzo, Maria di Martino, Andrea Pilloni
{"title":"多核苷酸和透明质酸(PN-HA)混合物加或不加去蛋白牛骨矿作为治疗深层骨下缺损的一种新方法:回顾性病例系列。","authors":"Francesco Cairo, Raffaele Cavalcanti, Luigi Barbato, Michele Nieri, Walter Castelluzzo, Maria di Martino, Andrea Pilloni","doi":"10.11607/prd.7065","DOIUrl":null,"url":null,"abstract":"<p><p>A mixture of polynucleotides and hyaluronic acid (PN-HA) has shown several modulating effects in the healing process. This study aimed to assess the safety and clinical performance of PN-HA alone or in association with deproteinized bovine bone mineral (DBBM) with papillary preservation flap (PPFs) in the treatment of residual pockets. A total of 43 patients with 55 infrabony defects were recruited; 30% were smokers. The mean baseline probing depth (PD) was 7.7 ± 1.9 mm with a corresponding mean recession (Rec) of 1.9 ±. 1.3 mm. The infrabony defect depth at the surgical measurement was 5.2 ± 2.1 mm. DBBM was applied at 56% of the defects, as they were determined to be noncontained defects based on clinical judgment. Healing was uneventful at all sites. After 1 year, PD reduction was 4.4 ± 1.8 mm, with a Rec increase of 1.0 ± 0.8 mm. The radiographic bone fill was 3.5 ±1.9 mm. The multilevel analysis showed that an absence of smoking habits was associated with improved PD reduction (P = .026) and bone gain (P = .039). PN-HA mixture is a safe product for periodontal surgery and seems to promote clinical benefits in the treatment of residual pockets associated with infrabony defects.</p>","PeriodicalId":94231,"journal":{"name":"The International journal of periodontics & restorative dentistry","volume":"0 0","pages":"153-163"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Polynucleotides and Hyaluronic Acid (PN-HA) Mixture With or Without Deproteinized Bovine Bone Mineral as a Novel Approach for the Treatment of Deep Infrabony Defects: A Retrospective Case Series.\",\"authors\":\"Francesco Cairo, Raffaele Cavalcanti, Luigi Barbato, Michele Nieri, Walter Castelluzzo, Maria di Martino, Andrea Pilloni\",\"doi\":\"10.11607/prd.7065\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A mixture of polynucleotides and hyaluronic acid (PN-HA) has shown several modulating effects in the healing process. This study aimed to assess the safety and clinical performance of PN-HA alone or in association with deproteinized bovine bone mineral (DBBM) with papillary preservation flap (PPFs) in the treatment of residual pockets. A total of 43 patients with 55 infrabony defects were recruited; 30% were smokers. The mean baseline probing depth (PD) was 7.7 ± 1.9 mm with a corresponding mean recession (Rec) of 1.9 ±. 1.3 mm. The infrabony defect depth at the surgical measurement was 5.2 ± 2.1 mm. DBBM was applied at 56% of the defects, as they were determined to be noncontained defects based on clinical judgment. Healing was uneventful at all sites. After 1 year, PD reduction was 4.4 ± 1.8 mm, with a Rec increase of 1.0 ± 0.8 mm. The radiographic bone fill was 3.5 ±1.9 mm. The multilevel analysis showed that an absence of smoking habits was associated with improved PD reduction (P = .026) and bone gain (P = .039). PN-HA mixture is a safe product for periodontal surgery and seems to promote clinical benefits in the treatment of residual pockets associated with infrabony defects.</p>\",\"PeriodicalId\":94231,\"journal\":{\"name\":\"The International journal of periodontics & restorative dentistry\",\"volume\":\"0 0\",\"pages\":\"153-163\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The International journal of periodontics & restorative dentistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.11607/prd.7065\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International journal of periodontics & restorative dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11607/prd.7065","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Polynucleotides and Hyaluronic Acid (PN-HA) Mixture With or Without Deproteinized Bovine Bone Mineral as a Novel Approach for the Treatment of Deep Infrabony Defects: A Retrospective Case Series.
A mixture of polynucleotides and hyaluronic acid (PN-HA) has shown several modulating effects in the healing process. This study aimed to assess the safety and clinical performance of PN-HA alone or in association with deproteinized bovine bone mineral (DBBM) with papillary preservation flap (PPFs) in the treatment of residual pockets. A total of 43 patients with 55 infrabony defects were recruited; 30% were smokers. The mean baseline probing depth (PD) was 7.7 ± 1.9 mm with a corresponding mean recession (Rec) of 1.9 ±. 1.3 mm. The infrabony defect depth at the surgical measurement was 5.2 ± 2.1 mm. DBBM was applied at 56% of the defects, as they were determined to be noncontained defects based on clinical judgment. Healing was uneventful at all sites. After 1 year, PD reduction was 4.4 ± 1.8 mm, with a Rec increase of 1.0 ± 0.8 mm. The radiographic bone fill was 3.5 ±1.9 mm. The multilevel analysis showed that an absence of smoking habits was associated with improved PD reduction (P = .026) and bone gain (P = .039). PN-HA mixture is a safe product for periodontal surgery and seems to promote clinical benefits in the treatment of residual pockets associated with infrabony defects.