治疗癌症的 RNA 疗法。

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Minh Nam Nguyen, Van Thai Than
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引用次数: 0

摘要

RNA 疗法是利用 RNA 分子治疗疾病(包括癌症)的一类药物。RNA 疗法针对疾病过程中涉及的特定基因或蛋白质,目的是阻断或改变它们的活性,最终阻止或逆转疾病的发展。在癌症治疗中使用 RNA 疗法已显示出巨大的潜力,因为这种疗法能够特异性地靶向癌细胞,同时不损伤健康细胞。这与传统的化疗和放射治疗形成了鲜明的对比,因为传统的化疗和放射治疗会损伤健康细胞,并产生令人不快的副作用。RNA 治疗领域发展迅速,目前正在开发几种用于癌症治疗的 RNA 分子,包括小干扰 RNA、microRNA、mRNA 和 RNA aptamers。每种类型的 RNA 分子都具有独特的性质和作用机制,可用于靶向和个性化癌症治疗。在本章中,我们将探讨用于癌症治疗的不同类型的 RNA 疗法、它们的作用机制以及在治疗不同类型癌症中的潜在应用。我们还将讨论开发和研究 RNA 治疗癌症所面临的挑战和机遇,以及这一前景广阔领域的未来展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RNA therapeutics in cancer treatment.

RNA therapeutics are a class of drugs that use RNA molecules to treat diseases, including cancer. RNA therapeutics work by targeting specific genes or proteins involved in the disease process, with the aim of blocking or altering their activity to ultimately halt or reverse the disease progression. The use of RNA therapeutics in cancer treatment has shown great potential, as they offer the ability to specifically target cancer cells while leaving healthy cells intact. This is in contrast to traditional chemotherapy and radiation treatments, which can damage healthy cells and cause unpleasant side effects. The field of RNA therapeutics is rapidly advancing, with several types of RNA molecules being developed for cancer treatment, including small interfering RNA, microRNA, mRNA, and RNA aptamers. Each type of RNA molecule has unique properties and mechanisms of action, allowing for targeted and personalized cancer treatments. In this chapter, we will explore the different types of RNA therapeutics used in cancer treatment, their mechanisms of action, and their potential applications in treating different types of cancer. We will also discuss the challenges and opportunities in the development and research of RNA therapeutics for cancer, as well as the future outlook for this promising field.

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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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