治疗糖尿病的 RNA 疗法。

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Yen Vy Nguyen Thi, Thuy Tien Ho, Safak Caglayan, Thamil Selvee Ramasamy, Dinh-Toi Chu
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引用次数: 0

摘要

糖尿病是一个持续存在的全球性问题,它影响着全世界超过 5.37 亿人的健康。糖尿病会引发许多严重的并发症,如果不及时发现和治疗,可能会导致患者死亡。糖尿病的一些并发症包括血管系统受损、中风风险增加、导致疼痛和麻木的神经系统疾病、导致失明的视网膜相关疾病,以及影响肾脏、心力衰竭、肌肉无力和肌肉萎缩的其他并发症。所有糖尿病并发症都会严重影响患者的健康。近来,基因疗法已成为治疗各种疾病的可行方法。DNA 和 RNA 是可以改变蛋白质结构和功能的靶分子,是治疗疾病,尤其是遗传性疾病的有效方法。RNA 疗法已被批准用于治疗脊髓性肌萎缩症和肌肉萎缩症等功能性系统疾病,因此引起了人们的浓厚兴趣。在本综述中,我们将介绍用于治疗糖尿病的 RNA 疗法的类型。特别是,我们深入探讨了治疗糖尿病的 RNA 疗法的作用机制,以及涉及这些 RNA 疗法测试的研究。最后,我们强调了目前对 RNA 疗法作用机制认识的局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RNA therapeutics for treatment of diabetes.

Diabetes is an ongoing global problem as it affects health of more than 537 million people around the world. Diabetes leaves many serious complications that affect patients and can cause death if not detected and treated promptly. Some of the complications of diabetes include impaired vascular system, increased risk of stroke, neurological diseases that cause pain and numbness, diseases related to the retina leading to blindness, and other complications affecting kidneys, heart failure, muscle weakness, muscle atrophy. All complications of diabetes seriously affect the health of patients. Recently, gene therapy has emerged as a viable treatment strategy for various diseases. DNA and RNA are among the target molecules that can change the structure and function of proteins and are effective methods of treating diseases, especially genetically inherited diseases. RNA therapeutics has attracted deep interest as it has been approved for application in the treatment of functional system disorders such as spinal muscular atrophy, and muscular dystrophy. In this review, we cover the types of RNA therapies considered for treatment of diabetes. In particular, we delve into the mechanism of action of RNA therapies for diabetes, and studies involving testing of these RNA therapies. Finally, we have highlighted the limitations of the current understanding in the mechanism of action of RNA therapies.

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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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