{"title":"硫化氢在肝纤维化中的作用和机制。","authors":"Shaoyu Mao, Xuemei Wang, Miaoqing Li, Hanshu Liu, Hongxia Liang","doi":"10.1016/j.niox.2024.02.002","DOIUrl":null,"url":null,"abstract":"<div><p>Hydrogen sulfide (H<sub>2</sub>S) is the third new gas signaling molecule in the human body after the discovery of NO and CO. Similar to NO, it has the functions of vasodilation, anti-inflammatory, antioxidant, and regulation of cell formation. Enzymes that can produce endogenous H<sub>2</sub>S, such as CSE, CSB, and 3-MST, are common in liver tissues and are important regulatory molecules in the liver. In the development of liver fibrosis, H<sub>2</sub>S concentration and expression of related enzymes change significantly, which makes it possible to use exogenous gases to treat liver diseases. This review summarizes the role of H<sub>2</sub>S in liver fibrosis and its complications induced by NAFLD and CCl<sub>4</sub>, and elaborates on the anti-liver fibrosis effect of H<sub>2</sub>S through the mechanism of reducing oxidative stress, inhibiting inflammation, regulating autophagy, regulating glucose and lipid metabolism, providing theoretical reference for further research on the treatment of liver fibrosis with H<sub>2</sub>S.</p></div>","PeriodicalId":19357,"journal":{"name":"Nitric oxide : biology and chemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role and mechanism of hydrogen sulfide in liver fibrosis\",\"authors\":\"Shaoyu Mao, Xuemei Wang, Miaoqing Li, Hanshu Liu, Hongxia Liang\",\"doi\":\"10.1016/j.niox.2024.02.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Hydrogen sulfide (H<sub>2</sub>S) is the third new gas signaling molecule in the human body after the discovery of NO and CO. Similar to NO, it has the functions of vasodilation, anti-inflammatory, antioxidant, and regulation of cell formation. Enzymes that can produce endogenous H<sub>2</sub>S, such as CSE, CSB, and 3-MST, are common in liver tissues and are important regulatory molecules in the liver. In the development of liver fibrosis, H<sub>2</sub>S concentration and expression of related enzymes change significantly, which makes it possible to use exogenous gases to treat liver diseases. This review summarizes the role of H<sub>2</sub>S in liver fibrosis and its complications induced by NAFLD and CCl<sub>4</sub>, and elaborates on the anti-liver fibrosis effect of H<sub>2</sub>S through the mechanism of reducing oxidative stress, inhibiting inflammation, regulating autophagy, regulating glucose and lipid metabolism, providing theoretical reference for further research on the treatment of liver fibrosis with H<sub>2</sub>S.</p></div>\",\"PeriodicalId\":19357,\"journal\":{\"name\":\"Nitric oxide : biology and chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-02-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nitric oxide : biology and chemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1089860324000193\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nitric oxide : biology and chemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1089860324000193","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
硫化氢（H2S）是继发现 NO 和 CO 之后，人体内第三种新的气体信号分子。与 NO 相似，它具有扩张血管、抗炎、抗氧化和调节细胞形成的功能。能产生内源性 H2S 的酶，如 CSE、CSB 和 3-MST，在肝组织中很常见，是肝脏中重要的调节分子。在肝纤维化的发展过程中，H2S 的浓度和相关酶的表达发生了显著变化，这使得利用外源性气体治疗肝病成为可能。本综述总结了H2S在非酒精性脂肪肝和CCl4诱发的肝纤维化及其并发症中的作用，阐述了H2S通过降低氧化应激、抑制炎症、调节自噬、调节糖脂代谢等机制抗肝纤维化的作用，为进一步研究H2S治疗肝纤维化提供理论参考。
The role and mechanism of hydrogen sulfide in liver fibrosis
Hydrogen sulfide (H2S) is the third new gas signaling molecule in the human body after the discovery of NO and CO. Similar to NO, it has the functions of vasodilation, anti-inflammatory, antioxidant, and regulation of cell formation. Enzymes that can produce endogenous H2S, such as CSE, CSB, and 3-MST, are common in liver tissues and are important regulatory molecules in the liver. In the development of liver fibrosis, H2S concentration and expression of related enzymes change significantly, which makes it possible to use exogenous gases to treat liver diseases. This review summarizes the role of H2S in liver fibrosis and its complications induced by NAFLD and CCl4, and elaborates on the anti-liver fibrosis effect of H2S through the mechanism of reducing oxidative stress, inhibiting inflammation, regulating autophagy, regulating glucose and lipid metabolism, providing theoretical reference for further research on the treatment of liver fibrosis with H2S.
期刊介绍：
Nitric Oxide includes original research, methodology papers and reviews relating to nitric oxide and other gasotransmitters such as hydrogen sulfide and carbon monoxide. Special emphasis is placed on the biological chemistry, physiology, pharmacology, enzymology and pathological significance of these molecules in human health and disease. The journal also accepts manuscripts relating to plant and microbial studies involving these molecules.
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