有童年创伤的精神健康成年人的前边缘白质微结构变化。

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Chanellé Hendrikse, Hilmar Klaus Lückhoff, Jean-Paul Fouché, Leigh L. van den Heuvel, Robin Emsley, Soraya Seedat, Stefan du Plessis
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引用次数: 0

摘要

童年创伤(CT)可能会影响大脑白质的微观结构;然而,很少有研究对生活在发展中国家、精神健康的成年人中不同类型的 CT 对白质微观结构的不同影响进行研究。在没有严重医疗或精神障碍的成年人中,我们调查了 CT(包括虐待和忽视)与边缘束分数各向异性(FA)之间的关系,之前的研究表明 CT 与边缘束分数各向异性有关。参与者接受了弥散张量成像检查,并填写了儿童创伤问卷。我们使用多变量方差分析模型来检验总CT和CT亚型对六个前边缘束FA的影响,并对年龄、性别和教育水平进行了调整。最终样本包括 69 名成年人(年龄 47 ± 17 岁;70% 为女性)。总体而言,CT 对相关束的 FA 有显著的主效应(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fronto-limbic white matter microstructural changes in psychiatrically healthy adults with childhood trauma

Fronto-limbic white matter microstructural changes in psychiatrically healthy adults with childhood trauma

Childhood trauma (CT) may influence brain white matter microstructure; however, few studies have examined the differential impact of distinct CT types on white matter microstructure in psychiatrically healthy adults living in a developing country. In adults without significant medical or psychiatric disorders, we investigated the association(s) between CT, including abuse and neglect, and fractional anisotropy (FA) of limbic tracts previously shown to be associated with CT. Participants underwent diffusion tensor imaging and completed the Childhood Trauma Questionnaire. Multivariate analysis of variance models were used to test the effects of total overall CT, as well as CT subtypes, on FA in six fronto-limbic tracts, adjusting for age, sex, and educational level. The final sample included 69 adults (age 47 ± 17 years; 70% female). Overall, CT had a significant main effect on FA for tracts of interest (p < .001). Greater CT severity was associated with lower FA for the bilateral and left stria terminalis (uncorrected) as well as the bilateral, left, and right anterior limb of the internal capsule (ALIC; corrected). Exposure to total non-violent/deprivational trauma specifically was associated with lower FA of the bilateral, left, and right ALIC, suggesting that distinct types of CT are associated with differential white matter changes in apparently healthy adults. The ALIC predominantly carries fibers connecting the thalamus with prefrontal cortical regions. Microstructural alterations in the ALIC may be associated with functional brain changes, which may be adaptive or increase the risk of accelerated age-related cognitive decline, maladaptive behaviors, and subsyndromal psychiatric symptoms.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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