阅读障碍患者和非阅读障碍患者灰质体积不对称研究。

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Kelly Nisbet, Avary Kostiw, Thi Kim Truc Huynh, Sukhmani Kaur Saggu, Dev Patel, Jacqueline Cummine
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引用次数: 0

摘要

旨在提高阅读障碍分类水平的脑成像工作强调了大脑前区(即额叶下回;IFG)和后区(即颞上回和边际上回)之间的重要关系。额叶下回的三个组成部分,即眶旁、三角区和厣,在多大程度上与后部区域,即颞上回和边际上回有不同的关系,还需要进一步阐明。有关前后连接性质的信息将有助于我们理解与阅读障碍相关的神经基础。成年参与者(38 人,其中 16 人患有阅读障碍)参加了一项核磁共振成像研究,该研究获得了高分辨率的结构扫描图像。研究人员提取了 IFG、颞上回和边际上回三个区域的体积不对称性。结果发现,与阅读障碍患者相比,熟练读者的眼眶旁和三角旁的左侧不对称程度更高,而眼底旁的右侧不对称程度更高。此外,对于熟练阅读者而非阅读障碍患者来说,三角旁与颞上回的左向不对称性有明显关联。对于有阅读障碍的人来说,IFG 的皮质不对称性以及与其他阅读相关脑区的相应连接与熟练读者有本质区别。我们将在 "从印刷到语音 "框架的背景下讨论我们的研究结果,以进一步了解与阅读障碍相关的神经基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A volumetric asymmetry study of gray matter in individuals with and without dyslexia

A volumetric asymmetry study of gray matter in individuals with and without dyslexia

Brain imaging work aimed at increased classification of dyslexia has underscored an important relationship between anterior (i.e., the inferior frontal gyrus; IFG) and posterior (i.e., superior temporal gyrus and supramarginal gyrus) brain regions. The extent to which the three components of the inferior frontal gyrus, namely the pars orbitalis, triangularis, and opercularis, are differentially related to the posterior regions, namely the superior temporal gyrus and supramarginal gyrus, needs further elucidation. Information about the nature of the anterior–posterior connections would facilitate our understanding of the neural underpinnings associated with dyslexia. Adult participants (N = 38; 16 with dyslexia) took part in an MRI study, whereby high-resolution structural scans were obtained. Volumetric asymmetry of the three regions of the IFG, the superior temporal gyrus, and the supramarginal gyrus was extracted. Significant differences were found for each of the three IFG regions, such that skilled readers had a greater leftward asymmetry of the orbitalis and triangularis, and greater rightward asymmetry of the opercularis, when compared to individuals with dyslexia. Furthermore, the pars triangularis was significantly associated with leftward asymmetry of the superior temporal gyrus for skilled but not dyslexic participants. For individuals with dyslexia, the cortical asymmetry of the IFG, and the corresponding connections with other reading-related brain regions, is inherently different from skilled readers. We discuss our findings in the context of the print-to-speech framework to further our understanding of the neural underpinnings associated with dyslexia.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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