造血干细胞移植患者的感恩、乐观和生活满意度以及患者报告的结果。

IF 3.3 2区医学 Q2 ONCOLOGY

Psycho‐Oncology Pub Date : 2024-02-01 DOI:10.1002/pon.6307

Hermioni L Amonoo, Elizabeth Daskalakis, Emma C Deary, Michelle Guo, Annabella C Boardman, Emma P Keane, Jeffrey A Lam, Richard A Newcomb, Lisa M Gudenkauf, Lydia A Brown, Henry K Onyeaka, Stephanie J Lee, Jeff C Huffman, Areej El-Jawahri

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引用次数: 0

摘要

目的：尽管有大量证据表明积极心理幸福感（PPWB）会影响其他医疗人群的PROs，但对于异基因造血干细胞移植（HSCT）幸存者中的血液恶性肿瘤患者，积极心理幸福感（PPWB）与患者报告结果（PROs，如生活质量[QOL]）之间的关系尚未进行广泛研究：我们对横断面数据进行了二次分析，研究了158名异体造血干细胞移植受者在移植后第100天的PPWB与PROs之间的关系。乐观、感恩、生活满意度和PROs（即QOL、焦虑、抑郁和创伤后应激障碍症状）分别使用生活取向测试-修订版、感恩问卷、生活满意度量表、癌症治疗功能评估-骨髓移植、医院焦虑抑郁量表和创伤后应激障碍（PTSD）检查表-民用版进行评估。我们使用线性回归和多元回归进行了所有分析，并控制了患者因素：结果：乐观与更好的 QOL 相关（β = 1.46；p 结论：乐观、感恩和满意度与 QOL 相关：异基因造血干细胞移植幸存者的乐观情绪、感激之情和对生活的满意度都与更好的 QOL 和更低的心理困扰水平相关。这些数据支持将 PPWB 作为造血干细胞移植康复过程中的治疗干预措施的研究。

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Gratitude, optimism, and satisfaction with life and patient-reported outcomes in patients undergoing hematopoietic stem cell transplantation.

Objective: Associations between positive psychological well-being (PPWB) and patient-reported outcomes (PROs, e.g., quality of life [QOL]) have yet to be studied extensively in patients with hematologic malignancies who are allogeneic hematopoietic stem cell transplant (HSCT) survivors, despite substantial evidence that PPWB impacts PROs of other medical populations.

Methods: We conducted a secondary analysis of cross-sectional data examining the association of PPWB and PROs at day 100 post-transplant among 158 allogeneic HSCT recipients. Optimism, gratitude, life satisfaction, and PROs (i.e., QOL, anxiety, depression, and PTSD symptoms) were assessed using the Life Orientation Test-Revised, Gratitude Questionnaire, Satisfaction with Life Scale, Functional Assessment of Cancer Therapy-Bone Marrow Transplant, Hospital Anxiety and Depression Scale, and Post-Traumatic Stress Disorder (PTSD) Checklist-Civilian Version, respectively. We used linear and multivariate regressions for all analyses and controlled for patient factors.

Results: Optimism was associated with better QOL (β = 1.46; p < 0.001) and lower levels of anxiety (β = -0.28; p < 0.001), depression (β = -0.31; p < 0.001), and PTSD (β = -0.58; p < 0.001). Gratitude was associated with better QOL (β = 1.11; p < 0.001) and lower levels of anxiety (β = -0.21; p = 0.001), depression (β = -0.14; p = 0.021), and PTSD (β = -0.32; p = 0.032). Finally, satisfaction with life was associated with better QOL (β = 1.26; p < 0.001) and lower levels of anxiety (β = -0.18; p < 0.001), depression (β = -0.21; p < 0.001), and PTSD (β = -0.49; p < 0.001).

Conclusion: Optimism, gratitude, and satisfaction with life were all associated with better QOL and lower levels of psychological distress in allogeneic HSCT survivors. These data support studies to harness PPWB as a therapeutic intervention for this population throughout HSCT recovery.

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来源期刊

Psycho‐Oncology 医学-心理学

CiteScore

6.30

自引率

8.30%

发文量

220

审稿时长

3-8 weeks

期刊介绍： Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology. This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues. Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.