靶向 LGR4-Wnt 可激活铁突变并逆转结直肠癌的耐药性。

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-02-14 DOI:10.1038/s43018-023-00714-9

引用次数: 0

摘要

我们的研究发现，LGR4-Wnt 信号通路决定了肿瘤细胞的铁突变和干性特征，从而赋予肿瘤细胞耐药性。因此，我们产生了一种针对LGR4的单克隆抗体，它能阻断LGR4-Wnt信号传导，并通过选择性促进铁突变来敏化耐化疗的结直肠癌肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer

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Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer

Our study reveals that the LGR4–Wnt signaling pathway dictates both ferroptosis and stemness traits to confer drug resistance to tumor cells. We thus generated a monoclonal antibody against LGR4 that blocks LGR4–Wnt signaling and sensitizes chemotherapy-resistant colorectal cancer tumors via selective promotion of ferroptosis.

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.