代谢综合征和 2 型糖尿病患者种植体表面的骨结合。

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Edmara T. P. Bergamo, Paula G. F. P. de Oliveira, Tiago M. B. Campos, Estevam A. Bonfante, Nick Tovar, Daniel Boczar, Vasudev Vivekanand Nayak, Paulo G. Coelho, Lukasz Witek
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引用次数: 0

摘要

这项体内研究评估了在代谢综合征(MS)和 2 型糖尿病(T2DM)诱导的临床前大型过渡模型中,不同表面形貌/化学性质的骨内植入物周围的骨愈合反应。15 只哥廷根小型猪被随机分为两组:(i) 对照组(正常饮食,n = 5)和 (ii) O/MS 组(用于诱导肥胖的食堂饮食,n = 10)。肥胖诱导后,肥胖/代谢综合征(O/MS)组的 5 只迷你猪又被随机分配到第三个实验组:(iii) T2DM(自助餐饮食 + 链脲佐菌素)。将不同表面形貌/化学性质的植入物:(i) 双酸蚀(DAE)和(ii) DAE 表面纳米羟基磷灰石涂层(NANO)植入受试者的右髂骨,并让其愈合 4 周。使用组织显微照片对种植体螺纹内的骨-种植体接触(%BIC)和骨面积占比(%BAFO)进行组织形态学评估。与 DAE 表面的种植体(%BIC = ~14%,%BAFO = ~28%,p .05)相比,NANO 表面的种植体显示出更高的 %BIC (~26%) 和 %BAFO (~35%)。考虑到这两个因素的统计评估表明,NANO 表面的 %BIC 和 %BAFO 明显高于 DAE 种植体,这与系统条件无关(p.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Osseointegration of implant surfaces in metabolic syndrome and type-2 diabetes mellitus

This in vivo study evaluated the bone healing response around endosteal implants with varying surface topography/chemistry in a preclinical, large transitional model induced with metabolic syndrome (MS) and type-2 diabetes mellitus (T2DM). Fifteen Göttingen minipigs were randomly distributed into two groups: (i) control (normal diet, n = 5) and (ii) O/MS (cafeteria diet for obesity induction, n = 10). Following obesity induction, five minipigs from the obese/metabolic syndrome (O/MS) group were further allocated, randomly, into the third experimental group: (iii) T2DM (cafeteria diet + streptozotocin). Implants with different surface topography/chemistry: (i) dual acid-etched (DAE) and (ii) nano-hydroxyapatite coating over the DAE surface (NANO), were placed into the right ilium of the subjects and allowed to heal for 4 weeks. Histomorphometric evaluation of bone-to-implant contact (%BIC) and bone area fraction occupancy (%BAFO) within implant threads were performed using histomicrographs. Implants with NANO surface presented significantly higher %BIC (~26%) and %BAFO (~35%) relative to implants with DAE surface (%BIC = ~14% and %BAFO = ~28%, p < .025). Data as a function of systemic condition presented significantly higher %BIC (~28%) and %BAFO (~42%) in the control group compared with the metabolically compromised groups (O/MS: %BIC = 14.35% and %BAFO = 26.24%, p < .021; T2DM: %BIC = 17.91% and %BAFO = 26.12%, p < .021) with no significant difference between O/MS and T2DM (p > .05). Statistical evaluation considering both factors demonstrated significantly higher %BIC and %BAFO for the NANO surface relative to DAE implant, independent of systemic condition (p < .05). The gain increase of %BIC and %BAFO for the NANO compared with DAE was more pronounced in O/MS and T2DM subjects. Osseointegration parameters were significantly reduced in metabolically compromised subjects compared with healthy subjects. Nanostructured hydroxyapatite-coated surfaces improved osseointegration relative to DAE, regardless of systemic condition.

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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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