细胞骨架串联:聚焦中间丝

IF 6 2区 生物学 Q1 CELL BIOLOGY
Lucas Pradeau-Phélut , Sandrine Etienne-Manneville
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引用次数: 0

摘要

细胞骨架由肌动蛋白微丝、微管和中间丝组成,对细胞运动和组织完整性至关重要。以前的研究主要集中于单个细胞骨架网络,而最近的研究强调了这些系统在粘附、迁移和分裂等基本细胞功能中的相互关联性。了解这些不同网络在时间和空间上的协调至关重要。这篇综述综述了目前关于这些网络之间错综复杂的相互作用的研究结果,强调了中间丝的关键作用。值得注意的是,这些中间丝通过直接的分子相互作用、细胞骨架连接体和形成分子桥的分子马达,以及更复杂的细胞内信号调节,与微丝和微管发生广泛的串扰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cytoskeletal crosstalk: A focus on intermediate filaments

The cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay between these networks, emphasizing the pivotal role of intermediate filaments. Notably, these filaments engage in extensive crosstalk with microfilaments and microtubules through direct molecular interactions, cytoskeletal linkers, and molecular motors that form molecular bridges, as well as via more complex regulation of intracellular signaling.

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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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