基于体重的人体胎儿死后微聚焦计算机断层扫描碘对比剂浸泡时间。

BJR open Pub Date : 2023-12-12 eCollection Date: 2024-01-01 DOI:10.1093/bjro/tzad006
Ian C Simcock, Susan C Shelmerdine, John Ciaran Hutchinson, Neil J Sebire, Owen J Arthurs
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引用次数: 0

摘要

研究目的本研究旨在评估使用三碘化钾作为造影剂,在进行人类胎儿死后微聚焦计算机断层扫描(micro-CT)成像前实现完全碘化所需的时间长度:方法:在对 157 名人类胎儿(死后体重范围为 2-298 克;胎龄范围为 12-37 周)进行微聚焦计算机断层扫描成像后,对最佳造影剂碘化进行了前瞻性评估。通过简单线性回归分析了哪些胎儿人口学因素能最准确地估计出最佳碘化时间:结果:与胎龄(r2 = 0.1384)相比,死后体重(r2 = 0.6435)与碘化时间的相关性更好,得出最佳拟合线 y = [0.0304 × 体重(克)] - 2.2103。临床使用时可简化为浸泡时间(天数)= [0.03 × 体重(克)] - 2.2。以此公式为例,一个 100 克的胎儿需要 5.2 天才能达到最佳对比度增强效果:结论:简化公式现在可用于提供显微 CT 成像前胎儿造影剂准备时间的估算,并可用于管理服务吞吐量和父母对胎儿返回的期望:根据经验数据得出的简单方程现在可用于估算人类胎儿死后显微 CT 成像的准备时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Body weight-based iodinated contrast immersion timing for human fetal postmortem microfocus computed tomography.

Objectives: The aim of this study was to evaluate the length of time required to achieve full iodination using potassium tri-iodide as a contrast agent, prior to human fetal postmortem microfocus computed tomography (micro-CT) imaging.

Methods: Prospective assessment of optimal contrast iodination was conducted across 157 human fetuses (postmortem weight range 2-298 g; gestational age range 12-37 weeks), following micro-CT imaging. Simple linear regression was conducted to analyse which fetal demographic factors could produce the most accurate estimate for optimal iodination time.

Results: Postmortem body weight (r2 = 0.6435) was better correlated with iodination time than gestational age (r2 = 0.1384), producing a line of best fit, y = [0.0304 × body weight (g)] - 2.2103. This can be simplified for clinical use whereby immersion time (days) = [0.03 × body weight (g)] - 2.2. Using this formula, for example, a 100-g fetus would take 5.2 days to reach optimal contrast enhancement.

Conclusions: The simplified equation can now be used to provide estimation times for fetal contrast preparation time prior to micro-CT imaging and can be used to manage service throughput and parental expectation for return of their fetus.

Advances in knowledge: A simple equation from empirical data can now be used to estimate preparation time for human fetal postmortem micro-CT imaging.

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