益生菌和维生素 C 对预防两组学龄前儿童上呼吸道症状的影响。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Nutrition Research and Practice Pub Date : 2024-02-01 Epub Date: 2023-12-01 DOI:10.4162/nrp.2024.18.1.98
Zuzana Paduchová, Zuzana Nagyová, Duolao Wang, Jana Muchová
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引用次数: 0

摘要

背景/目的:两项针对儿童的研究调查了Lab4益生菌和维生素C组合预防上呼吸道感染(URTI)的疗效。我们的目的是汇集PROCHILD研究(ISRCTN28722693)中57名学龄前儿童的数据集和PROCHILD-2研究(ISRCTN26587549)中50名学龄前匹配队列的数据集,评估益生菌/维生素C组合对预防上呼吸道症状的影响,并利用详细的个体水平数据提供更可靠的效果评估:儿童每天补充多菌株益生菌(1.25×1010 cfu/片,由嗜酸乳杆菌CUL21和CUL60、双歧杆菌CUL20和动物双歧杆菌亚种乳杆菌CUL34的两种菌株组成)加50毫克维生素C或安慰剂,持续6个月:在对个体参与者数据(按方案人群)的汇总分析中,观察到活性组与安慰剂组相比,典型 URTI 症状的发生率(-25%;95% 置信区间 [CI],0.66, 0.85;P < 0.0001)和持续时间(-14.9 天;95% CI,-24.8, -5.1;P = 0.0030)显著降低。学龄前缺勤率(IR 比值,0.75;95% CI,0.66,0.86;P < 0.0001)、儿科就诊率(IR 比值,0.56;95% CI,0.47,0.68;P < 0.0001)和抗生素使用率(IR 比值,0.53;95% CI,0.39,0.71;P < 0.0001)也显著降低:结论:两项研究对可比学龄前群体的汇总分析结果表明,补充益生菌和维生素 C 组合有益于预防和治疗尿路感染症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The impact of probiotics and vitamin C on the prevention of upper respiratory tract symptoms in two preschool children cohorts.

Background/objectives: The efficacy of Lab4 probiotic and vitamin C combination on the prevention of upper respiratory tract infections (URTIs) was investigated in two studies with children. Our objective was to pool dataset of 57 preschool children from the PROCHILD study (ISRCTN28722693) and the dataset of 50 preschool matched cohort from the PROCHILD-2 study (ISRCTN26587549) to evaluate the impact of probiotic/vitamin C combination on the prevention of upper respiratory tract symptoms and provide a more robust assessment of effect using detailed individual level data.

Subjects/methods: The children were supplemented daily for 6 months with either the multistrain probiotic (1.25×1010 cfu/tablet consisting of two strains of Lactobacillus acidophilus CUL21 and CUL60, Bifidobacterium bifidum CUL20 and Bifidobacterium animalis subsp. lactis CUL34) plus 50 mg vitamin C or a placebo.

Results: In the pooled analysis of the individual participant data (per protocol population), significant reductions were observed for the incidence (-25%; 95% confidence interval [CI], 0.66, 0.85; P < 0.0001) and duration (-14.9 days; 95% CI, -24.8, -5.1; P = 0.0030) of typical URTI symptoms in the active group compared with the placebo. The incidence rates of absenteeism from preschool (IR ratio, 0.75; 95% CI, 0.66, 0.86; P < 0.0001), paediatric visits (IR ratio, 0.56; 95% CI, 0.47; 0.68; P < 0.0001) and antibiotic usage (IR ratio, 0.53; 95% CI, 0.39, 0.71; P < 0.0001) were also significantly reduced.

Conclusion: The pooled analysis findings of comparable preschool cohorts from two studies indicate that the supplementation with probiotic and vitamin C combination is beneficial in the prevention and management of URTI symptoms.

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来源期刊
Nutrition Research and Practice
Nutrition Research and Practice NUTRITION & DIETETICS-
CiteScore
3.50
自引率
4.20%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Nutrition Research and Practice (NRP) is an official journal, jointly published by the Korean Nutrition Society and the Korean Society of Community Nutrition since 2007. The journal had been published quarterly at the initial stage and has been published bimonthly since 2010. NRP aims to stimulate research and practice across diverse areas of human nutrition. The Journal publishes peer-reviewed original manuscripts on nutrition biochemistry and metabolism, community nutrition, nutrition and disease management, nutritional epidemiology, nutrition education, foodservice management in the following categories: Original Research Articles, Notes, Communications, and Reviews. Reviews will be received by the invitation of the editors only. Statements made and opinions expressed in the manuscripts published in this Journal represent the views of authors and do not necessarily reflect the opinion of the Societies.
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