山茶叶中的五环三萜类化合物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-07-03 DOI:10.1080/14786419.2024.2315597

Thanh Tuyen Nguyen , Duc Tuan Cao , Hong Ngoc Tran , Thi Hanh Nguyen , Gia Dien Pham , Van Hieu Tran , Quang Duong Pham , Thi Thu Thuy Tran , Minh Tin Vu , Dinh Hoang Vu

{"title":"山茶叶中的五环三萜类化合物。","authors":"Thanh Tuyen Nguyen , Duc Tuan Cao , Hong Ngoc Tran , Thi Hanh Nguyen , Gia Dien Pham , Van Hieu Tran , Quang Duong Pham , Thi Thu Thuy Tran , Minh Tin Vu , Dinh Hoang Vu","doi":"10.1080/14786419.2024.2315597","DOIUrl":null,"url":null,"abstract":"<div><div>Nine pentacyclic triterpene derivatives including new 3-O-cis-p-coumaroyl trichadenic acid B (1) and two new ursane-type triterpene derivatives, 11α,12-[1-(methyl)-2-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol (2) and 11α,12-[2-(methyl)-1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol (3) were isolated from the leaves of Camellia hakodae Ninh., along with six known compounds (4-9). This is the first report on pentacyclic triterpenoids from this species. New compounds 1-3 and compound 7 were tested for cytotoxic activity against four human cancer cell lines (KB; Hep-G2; Lu; MCF-7) using the MTT assay to show moderate activity.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 13","pages":"Pages 3787-3792"},"PeriodicalIF":1.6000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pentacyclic triterpenes from the leaves of Camellia hakodae Ninh\",\"authors\":\"Thanh Tuyen Nguyen , Duc Tuan Cao , Hong Ngoc Tran , Thi Hanh Nguyen , Gia Dien Pham , Van Hieu Tran , Quang Duong Pham , Thi Thu Thuy Tran , Minh Tin Vu , Dinh Hoang Vu\",\"doi\":\"10.1080/14786419.2024.2315597\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Nine pentacyclic triterpene derivatives including new 3-O-cis-p-coumaroyl trichadenic acid B (1) and two new ursane-type triterpene derivatives, 11α,12-[1-(methyl)-2-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol (2) and 11α,12-[2-(methyl)-1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol (3) were isolated from the leaves of Camellia hakodae Ninh., along with six known compounds (4-9). This is the first report on pentacyclic triterpenoids from this species. New compounds 1-3 and compound 7 were tested for cytotoxic activity against four human cancer cell lines (KB; Hep-G2; Lu; MCF-7) using the MTT assay to show moderate activity.</div></div>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\"39 13\",\"pages\":\"Pages 3787-3792\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1478641924000846\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641924000846","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

摘要

九种五环三萜衍生物，包括新的 3-O-顺式-对香豆酰基毛茶烯酸 B（1）和两种新的熊烷型三萜衍生物，即 11α,12-[1-(甲基)-2-(4-羟基-3-甲氧基苯基)乙烷-1、2-dioxy]-urs-12-ene-3β-ol (2) 和 11α,12-[2-(methyl)-1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol (3)。,以及六种已知化合物（4-9）。这是首次报道该物种的五环三萜类化合物。利用 MTT 法测试了新化合物 1-3 和化合物 7 对四种人类癌细胞株（KB、Hep-G2、Lu、MCF-7）的细胞毒性活性，结果显示活性适中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Pentacyclic triterpenes from the leaves of Camellia hakodae Ninh

Nine pentacyclic triterpene derivatives including new 3-O-cis-p-coumaroyl trichadenic acid B (1) and two new ursane-type triterpene derivatives, 11α,12-[1-(methyl)-2-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol (2) and 11α,12-[2-(methyl)-1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol (3) were isolated from the leaves of Camellia hakodae Ninh., along with six known compounds (4-9). This is the first report on pentacyclic triterpenoids from this species. New compounds 1-3 and compound 7 were tested for cytotoxic activity against four human cancer cell lines (KB; Hep-G2; Lu; MCF-7) using the MTT assay to show moderate activity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.