{"title":"伴有特应性皮炎的眼内晶状体脱位病例的晶状体囊病理学特征。","authors":"Koji Komatsu, Yoichiro Masuda, Ai Iwauchi, Hoshiho Kubota, Masanobu Iida, Kosuke Ichihara, Masami Iwamoto, Kenji Kawai, Naoki Yamamoto, Masayuki Shimoda, Tadashi Nakano","doi":"10.1097/j.jcrs.0000000000001413","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To explore lens capsule pathological characteristics in intraocular lens (IOL) dislocation after cataract surgery in patients with atopic dermatitis (AD).</p><p><strong>Setting: </strong>University hospital department of ophthalmology.</p><p><strong>Design: </strong>Case series with clinicopathological correlations.</p><p><strong>Methods: </strong>Lens capsules and surrounding tissues excised during surgery from eyes with AD (AD group) and eyes without AD (non-AD group) with IOL dislocation were histologically evaluated. Hematoxylin and eosin staining was used to assess abnormal changes in lens epithelial cells (LECs). Masson trichrome staining distinguished the fibrous metaplasia around the lens capsule into high-density and low-density fibrosis. Capsular splitting (thinning) was identified in both stained preparations.</p><p><strong>Results: </strong>The IOL dislocation morphology in the AD group (10 eyes of 10 patients) included 7 cases of capsular bag dislocation (CBD) and 3 cases of dead bag syndrome (DBS), with an average duration to IOL dislocation of 11.5 ± 5.6 years. All patients in the non-AD group (12 eyes of 12 patients) had CBD, averaging 10.2 ± 5.7 years to dislocation. Abnormal LECs, low-density fibrosis, and capsular splitting were observed in 9 (90), 9 (90), and 6 (60) of the patients in the AD group compared with 6 (50), 3 (25), and 2 (18), respectively, in the non-AD group (total n [%]).</p><p><strong>Conclusions: </strong>Compared with the non-AD group, the AD group exhibited higher frequencies of morphological changes in LECs, low-density fibrosis around the lens capsule, and capsular splitting characteristics of DBS. These results suggest LEC degeneration and increased lens capsule fragility occurred in patients with AD.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":"611-617"},"PeriodicalIF":2.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146175/pdf/","citationCount":"0","resultStr":"{\"title\":\"Lens capsule pathological characteristics in cases of intraocular lens dislocation with atopic dermatitis.\",\"authors\":\"Koji Komatsu, Yoichiro Masuda, Ai Iwauchi, Hoshiho Kubota, Masanobu Iida, Kosuke Ichihara, Masami Iwamoto, Kenji Kawai, Naoki Yamamoto, Masayuki Shimoda, Tadashi Nakano\",\"doi\":\"10.1097/j.jcrs.0000000000001413\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To explore lens capsule pathological characteristics in intraocular lens (IOL) dislocation after cataract surgery in patients with atopic dermatitis (AD).</p><p><strong>Setting: </strong>University hospital department of ophthalmology.</p><p><strong>Design: </strong>Case series with clinicopathological correlations.</p><p><strong>Methods: </strong>Lens capsules and surrounding tissues excised during surgery from eyes with AD (AD group) and eyes without AD (non-AD group) with IOL dislocation were histologically evaluated. Hematoxylin and eosin staining was used to assess abnormal changes in lens epithelial cells (LECs). Masson trichrome staining distinguished the fibrous metaplasia around the lens capsule into high-density and low-density fibrosis. Capsular splitting (thinning) was identified in both stained preparations.</p><p><strong>Results: </strong>The IOL dislocation morphology in the AD group (10 eyes of 10 patients) included 7 cases of capsular bag dislocation (CBD) and 3 cases of dead bag syndrome (DBS), with an average duration to IOL dislocation of 11.5 ± 5.6 years. All patients in the non-AD group (12 eyes of 12 patients) had CBD, averaging 10.2 ± 5.7 years to dislocation. Abnormal LECs, low-density fibrosis, and capsular splitting were observed in 9 (90), 9 (90), and 6 (60) of the patients in the AD group compared with 6 (50), 3 (25), and 2 (18), respectively, in the non-AD group (total n [%]).</p><p><strong>Conclusions: </strong>Compared with the non-AD group, the AD group exhibited higher frequencies of morphological changes in LECs, low-density fibrosis around the lens capsule, and capsular splitting characteristics of DBS. These results suggest LEC degeneration and increased lens capsule fragility occurred in patients with AD.</p>\",\"PeriodicalId\":15214,\"journal\":{\"name\":\"Journal of cataract and refractive surgery\",\"volume\":\" \",\"pages\":\"611-617\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146175/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cataract and refractive surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/j.jcrs.0000000000001413\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cataract and refractive surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/j.jcrs.0000000000001413","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨特应性皮炎（AD）患者白内障手术后眼内晶状体（IOL）脱位的晶状体囊病理特征：设计：设计：与临床病理学相关的病例系列：对患有特应性皮炎（AD）和未患有特应性皮炎（非 AD）的人工晶体脱位患者手术中切除的晶状体囊和周围组织进行组织学评估。采用苏木精和伊红染色法评估晶状体上皮细胞（LEC）的异常变化。Masson 三色染色法将晶状体囊周围的纤维增生分为高密度和低密度纤维化。在两种染色制剂中均可发现晶状体囊分裂（变薄）：AD组（10名患者的10只眼睛）的人工晶体脱位形态包括7例囊袋脱位（CBD）和3例死袋综合征（DBS），人工晶体脱位的平均持续时间为（11.5±5.6）年。非 AD 组的所有患者（12 位患者中的 12 只眼睛）都有 CBD，平均脱位时间为 10.2±5.7 年。在AD组患者中，分别有9（90）、9（90）和6（60）只眼观察到LEC异常、低密度纤维化和囊膜裂开，而在非AD组患者中，分别有6（50）、3（25）和2（18）只眼观察到LEC异常、低密度纤维化和囊膜裂开（总计n（%））：与非 AD 组相比，AD 组的 LECs 形态学变化、晶状体囊周围的低密度纤维化和 DBS 的囊分裂特征频率更高。这些结果表明，AD 患者的晶状体上皮细胞发生变性，晶状体囊脆性增加。
Lens capsule pathological characteristics in cases of intraocular lens dislocation with atopic dermatitis.
Purpose: To explore lens capsule pathological characteristics in intraocular lens (IOL) dislocation after cataract surgery in patients with atopic dermatitis (AD).
Setting: University hospital department of ophthalmology.
Design: Case series with clinicopathological correlations.
Methods: Lens capsules and surrounding tissues excised during surgery from eyes with AD (AD group) and eyes without AD (non-AD group) with IOL dislocation were histologically evaluated. Hematoxylin and eosin staining was used to assess abnormal changes in lens epithelial cells (LECs). Masson trichrome staining distinguished the fibrous metaplasia around the lens capsule into high-density and low-density fibrosis. Capsular splitting (thinning) was identified in both stained preparations.
Results: The IOL dislocation morphology in the AD group (10 eyes of 10 patients) included 7 cases of capsular bag dislocation (CBD) and 3 cases of dead bag syndrome (DBS), with an average duration to IOL dislocation of 11.5 ± 5.6 years. All patients in the non-AD group (12 eyes of 12 patients) had CBD, averaging 10.2 ± 5.7 years to dislocation. Abnormal LECs, low-density fibrosis, and capsular splitting were observed in 9 (90), 9 (90), and 6 (60) of the patients in the AD group compared with 6 (50), 3 (25), and 2 (18), respectively, in the non-AD group (total n [%]).
Conclusions: Compared with the non-AD group, the AD group exhibited higher frequencies of morphological changes in LECs, low-density fibrosis around the lens capsule, and capsular splitting characteristics of DBS. These results suggest LEC degeneration and increased lens capsule fragility occurred in patients with AD.
期刊介绍：
The Journal of Cataract & Refractive Surgery (JCRS), a preeminent peer-reviewed monthly ophthalmology publication, is the official journal of the American Society of Cataract and Refractive Surgery (ASCRS) and the European Society of Cataract and Refractive Surgeons (ESCRS).
JCRS publishes high quality articles on all aspects of anterior segment surgery. In addition to original clinical studies, the journal features a consultation section, practical techniques, important cases, and reviews as well as basic science articles.
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