菲律宾大马尼拉市交通执法人员体内铅与循环炎症标记物之间的关系:MMDA 交通执法人员健康研究。

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Zypher Jude G Regencia, Wenyuan Zhao, Carolina Torres-Roja, Byron C Jones, Emmanuel S Baja
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引用次数: 0

摘要

目的:多项流行病学研究表明,铅(Pb)暴露与诱导氧化应激和促进炎症反应有关。我们进行了一项受试者内研究(重复测量研究),以评估血铅(B-Pb)和趾甲铅(T-Pb)浓度与循环炎症标志物之间的关系:我们评估了马尼拉大都会发展局(MMDA)交通执法人员健康研究中 158 名交通执法人员的 B-Pb 浓度和 T-Pb 浓度与循环炎症指标、可溶性细胞内粘附分子-1(s-ICAM-1)、可溶性血管粘附分子-1(s-VCAM-1)和高敏 C 反应蛋白(hs-CRP)之间的关系。采用随机特定对象截距的线性混合效应模型来估计B-铅和T-铅暴露与循环炎症指标之间的关系,并对混杂因素进行了调整:交通执法人员均为中年男性(89.4%),平均年龄(± SD)为 37.1 岁 ± 8.9 岁,共进行了 293 次有效的炎症指标测量。B-Pb 浓度与 hs-CRP 水平的升高有关。B-Pb 每增加 10%,hs-CRP 水平就会增加 5.7% [95% 置信区间 (95% CI):1.3-10.1]。然而,B-Pb 与 s-ICAM-1 和 s-VCAM-1 无关。此外,T-铅与所有循环中的炎症标记物之间都没有关联:结论:低浓度的铅可能会增加交通执法人员的 hs-CRP。此外,该研究还表明,铅通过氧化和炎症途径可能在心血管疾病的发展中起着至关重要的作用。此外,MMDA 和劳动就业部可将我们的研究结果作为证据,对 MMDA 和其他交通执法人员进行血液重金属(尤其是铅含量)的常规筛查,作为他们每年体检的一部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between lead and circulating markers of inflammation among traffic enforcers in Metro Manila, Philippines: the MMDA traffic enforcer's health study.

Purpose: Several epidemiological studies have linked lead (Pb) exposure to induced oxidative stress and the promotion of inflammatory response. We performed a within-subjects study (repeated measures study) to evaluate the relationship between the concentration of blood lead (B-Pb) and toenail lead (T-Pb) and circulating markers of inflammation.

Methods: We evaluated the associations between B-Pb concentrations and T-Pb concentrations and circulating markers of inflammation, soluble intracellular adhesion molecule-1 (s-ICAM-1), soluble vascular adhesion molecule-1 (s-VCAM-1), and high-sensitivity C-reactive protein (hs-CRP) on 158 traffic enforcers from the Metropolitan Manila Development Authority (MMDA) traffic enforcer's health study. Linear mixed-effects models with random subject-specific intercepts were fitted to estimate the association between B-Pb and T-Pb exposure and circulating markers of inflammation, adjusting for confounding factors.

Results: Traffic enforcers were middle-aged men (89.4%) with a mean age (± SD) of 37.1 years ± 8.9 years and had a total of 293 valid markers of inflammation measurements. B-Pb concentration was related to increased hs-CRP levels. A 10% increase in B-Pb was associated with a 5.7% increase in hs-CRP level [95% confidence interval (95% CI): 1.3-10.1]. However, B-Pb was not associated with s-ICAM-1 and s-VCAM-1. Furthermore, no associations were observed between T-Pb and all the circulating markers of inflammation.

Conclusions: Low-level B-Pb may increase hs-CRP among traffic enforcers. Moreover, the study suggests that Pb via the oxidative and inflammation pathways may have an essential role in the development of cardiovascular disease. Furthermore, MMDA and the Department of Labor and Employment can use our study's findings as evidence to conduct routine screening of blood heavy metals, especially Pb, among MMDA and other traffic enforcers as part of their yearly medical examination.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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