从全球视角看待慢性自发性荨麻疹的减量治疗:荨麻疹卓越参考中心 SDown-CSU 研究结果。

IF 4.6 2区 医学 Q2 ALLERGY
Murat Türk, Emek Kocatürk, Ragıp Ertaş, Luis Felipe Ensina, Silvia Mariel Ferrucci, Clive Grattan, Christian Vestergaard, Torsten Zuberbier, Marcus Maurer, Ana Maria Giménez-Arnau
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引用次数: 0

摘要

背景:尽管近年来慢性自发性荨麻疹(CSU)的治疗取得了重大进展,但对于应答者何时以及如何减量治疗仍缺乏明确的指导。本研究旨在从全球视角研究慢性自发性荨麻疹治疗不同步骤的减量方法:"慢性自发性荨麻疹减量治疗"(SDown-CSU)是一项国际性、多中心、观察性、横断面、基于调查的荨麻疹卓越参考中心(UCARE)网络研究。问卷包括 48 个问题,由 UCARE 网络的医生填写:分析了来自 81 个 UCARE 和 34 个国家的 103 名医生填写的调查问卷。78%的参与者回答说,他们拥有由其专业协会编写的国家荨麻疹管理指南,28%的参与者回答说,他们必须根据中央卫生筹资组织提出的监管指南开展工作。在这些国家级建议中,分别有 72% 和 58.7% 没有详细说明何时和/或如何停止 CSU 治疗。尤其缺乏关于抗组胺药和环孢素的详细信息。奥马珠单抗和环孢素一般不适用预定的最长疗程(分别为 81% 和 82%)。几乎所有 UCARE 都在首次控制状态后 6 个月内停用奥马珠单抗,42% 的 UCARE 在 6 个月后停用环孢素,无论控制状态如何:SDown-CSU研究的结果清楚地表明,全球都需要关于CSU减量治疗过程的指导。此外,该研究还提供了一种适用于 CSU 各个治疗阶段的减量算法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A global perspective on stepping down chronic spontaneous urticaria treatment: Results of the Urticaria Centers of Reference and Excellence SDown-CSU study

A global perspective on stepping down chronic spontaneous urticaria treatment: Results of the Urticaria Centers of Reference and Excellence SDown-CSU study

Background

Although there have been significant advances in the treatment of chronic spontaneous urticaria (CSU) in recent years, there remains a lack of clear guidance on when and how to step down treatment in responders. This study aims to investigate stepping down approaches of different steps of CSU treatment from a global perspective.

Methods

“Stepping down chronic spontaneous urticaria treatment” (SDown-CSU) is an international, multicenter, observational, cross-sectional, survey-based study of the Urticaria Centers of Reference and Excellence (UCARE) network. The questionnaire included 48 questions completed by physicians in the UCARE network.

Results

Surveys completed by 103 physicians from 81 UCAREs and 34 countries were analyzed. Seventy-eight percent of the participants responded that they had a national urticaria management guideline written by their professional societies and 28% responded that they had to operate under a regulatory guideline proposed by central health funding organizations. Seventy-two and 58.7% of these national recommendations do not contain any detailed information on when and/or how CSU treatment should be discontinued. There was a lack of detailed information on antihistamines and cyclosporine in particular. A predefined maximum duration was generally not applicable to omalizumab and cyclosporine (81% and 82%, respectively). Nearly all UCAREs step down omalizumab within 6 months from the first controlled status and 42% discontinue cyclosporine after 6 months regardless of the control status.

Conclusions

The findings from the SDown-CSU study clearly highlight a global need for guidance on the process of stepping down treatment in CSU. Additionally, the study offers a step-down algorithm applicable to all stages of CSU treatment.

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来源期刊
Clinical and Translational Allergy
Clinical and Translational Allergy Immunology and Microbiology-Immunology
CiteScore
7.50
自引率
4.50%
发文量
117
审稿时长
12 weeks
期刊介绍: Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.
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