在大流行期间,魁北克省一组成年人对 COVID-19 疫苗的意向和犹豫态度的变化。

IF 4.1 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Human Vaccines & Immunotherapeutics Pub Date : 2024-12-31 Epub Date: 2024-02-12 DOI:10.1080/21645515.2024.2309006
Maude Dionne, Louis Rochette, Denis Hamel, Ève Dube
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引用次数: 0

摘要

虽然 COVID-19 疫苗在魁北克的初次接种率很高,但随后的加强剂量接种率却有所下降。本文介绍了两年来疫苗接种意向、自我报告的疫苗接种行为和疫苗接种犹豫的演变情况。2020 年 3 月至 2023 年 3 月期间,我们在魁北克省进行了一系列横断面调查,每两周通过网络小组招募 3,330 名成年人作为代表性样本。小组成员可在项目过程中多次回答问题。建立受访者队列是为了评估人们对 COVID-19 疫苗的态度和行为是如何演变的。我们进行了描述性统计和多变量逻辑回归。在 2021 年秋季(阶段 1)没有或很少打算接种疫苗的 1,914 人中,有 1,476 人(77%)表示在 2023 年冬季(阶段 2)至少接种过两剂疫苗。不相信阴谋论(OR = 2.08,95% CI:1.65-2.64)、担心感染 COVID-19(OR = 2.12,95% CI:1.65-2.73)和不居住在农村地区(其他地区的 OR 为 2.27,95% CI:1.58-3.28;1.66,95% CI:1.23-2.26;1.82,95% CI:1.23-2.73)是与第 2 期接种疫苗相关的三个主要因素。在第一阶段不犹豫的 11,117 人中,有 1,335 人(12%)在第二阶段开始犹豫。与疫苗接种犹豫不决明显相关的三个主要因素是:坚持阴谋论(OR = 2.28,95% CI:1.95-2.66)、女性(OR = 1.67,95% CI:1.48-1.90)和 65 岁以下。女性(OR = 1.67,95% CI:1.48-1.90)和年龄小于 65 岁(18-34 岁、35-49 岁和 50-64 岁与 65 岁及以上相比,OR 分别为 2.82,95% CI:2.32-3.44;2.39,95% CI:2.00-2.86 和 1.82,95% CI:1.55-2.15)。随着大流行的结束,监测疫苗态度和接种率的变化将非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Change in intention and hesitancy regarding COVID-19 vaccines in a cohort of adults in Quebec during the pandemic.

Although COVID-19 vaccine uptake was high in Quebec for the primary series, vaccine acceptance decreased for the subsequent booster doses. This article presents the evolution of vaccine intention, self-reported vaccination behaviors, and vaccine hesitancy over 2 years. A series of cross-sectional surveys were conducted in Quebec between March 2020 and March 2023, with a representative sample of 3,330 adults recruited biweekly via a Web panel. Panelists could have answered multiple times over the course of the project. A cohort of respondents was created to assess how attitudes and behaviors about COVID-19 vaccines evolved. Descriptive statistics and multivariate logistic regressions were performed. Among the 1,914 individuals with no or low intention of getting vaccinated in Fall 2021 (Period 1), 1,476 (77%) reported having received at least two doses in the Winter 2023 (Period 2). Not believing in conspiracy theory (OR = 2.08, 95% CI: 1.65-2.64), being worried about catching COVID-19 (OR = 2.12, 95% CI: 1.65-2.73) and not living in a rural area (ORs of other areas are 2.27, 95% CI: 1.58-3.28; 1.66, 95% CI: 1.23-2.26; 1.82 95% CI: 1.23-2.73) were the three main factors associated with being vaccinated at Period 2. Among the 11,117 individuals not hesitant at Period 1, 1,335 (12%) became hesitant at Period 2. The three main factors significantly associated with becoming vaccine hesitant were the adherence to conspiracy theories (OR = 2.28, 95% CI: 1.95-2.66), being a female (OR = 1.67, 95% CI: 1.48-1.90) and being younger than 65 years old (the ORs for 18-34, 35-49, and 50-64 compared with 65 and over are 2.82, 95% CI: 2.32-3.44; 2.39, 95% CI: 2.00-2.86 and 1.82, 95% CI: 1.55-2.15 respectively). As the pandemic is over, monitoring the evolution of vaccine attitudes and uptake will be important.

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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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