通过基于 DTI 的概率性束线图识别精神分裂症的白质束改变:一项多点协调研究。

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Young Tak Jo, Sung Woo Joo, Woohyeok Choi, Soohyun Joe, Jungsun Lee
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引用次数: 0

摘要

导言:有研究认为,精神分裂症涉及大脑功能区之间的连接障碍和白质结构紊乱。因此,弥散张量成像(DTI)被广泛用于研究精神分裂症。然而,以往的研究大多采用基于感兴趣区(ROI)的方法。因此,我们在本研究中采用了概率束成像法来揭示精神分裂症大脑白质束的改变:方法:共调查了四个不同的数据集,包括 189 名精神分裂症患者和 213 名健康对照者。我们通过 dMRIharmonisation 对原始弥散 MRI 数据进行了回顾性协调,并使用 FMRIB 软件库(FSL)进行了概率牵引成像。然后比较了患者和对照组不同 ROI 之间的连接性。此外,我们还评估了连接概率与精神分裂症患者的症状和认知指标之间的关系:结果:在对多重比较进行 Bonferroni 校正后,精神分裂症患者与健康对照组之间有 11 个不同的神经束存在显著差异。其中许多束与基底节或皮质纹状体结构有关,这与目前强调纹状体功能障碍的文献一致。此外,我们还发现这些神经束与语言、执行功能或处理速度等少数认知测量指标之间存在统计学意义上的显著关系:我们使用大型、统一的弥散核磁共振成像数据集进行了概率束成像,这增强了我们研究的统计能力。值得注意的是,本研究中发现的大多数束,尤其是胼胝体和皮质-纹状体流线,在目前的文献中已被认为与精神分裂症有关。我们建议利用统一的数据对这些脑区进行进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
White matter tract alterations in schizophrenia identified by DTI-based probabilistic tractography: a multisite harmonisation study.

Introduction: It has been suggested that schizophrenia involves dysconnectivity between functional brain regions and also the white matter structural disorganisation. Thus, diffusion tensor imaging (DTI) has widely been used for studying schizophrenia. However, most previous studies have used the region of interest (ROI) based approach. We, therefore, performed the probabilistic tractography method in this study to reveal the alterations of white matter tracts in the schizophrenia brain.

Methods: A total of four different datasets consisted of 189 patients with schizophrenia and 213 healthy controls were investigated. We performed retrospective harmonisation of raw diffusion MRI data by dMRIharmonisation and used the FMRIB Software Library (FSL) for probabilistic tractography. The connectivities between different ROIs were then compared between patients and controls. Furthermore, we evaluated the relationship between the connection probabilities and the symptoms and cognitive measures in patients with schizophrenia.

Results: After applying Bonferroni correction for multiple comparisons, 11 different tracts showed significant differences between patients with schizophrenia and healthy controls. Many of these tracts were associated with the basal ganglia or cortico-striatal structures, which aligns with the current literature highlighting striatal dysfunction. Moreover, we found that these tracts demonstrated statistically significant relationships with few cognitive measures related to language, executive function, or processing speed.

Conclusion: We performed probabilistic tractography using a large, harmonised dataset of diffusion MRI data, which enhanced the statistical power of our study. It is important to note that most of the tracts identified in this study, particularly callosal and cortico-striatal streamlines, have been previously implicated in schizophrenia within the current literature. Further research with harmonised data focusing specifically on these brain regions could be recommended.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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