[急性症状性癫痫发作。肿瘤儿科系列的临床脑电图病因描述和预后]。

IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY
P Ivarola, B González, I Tedeschini, F Córdoba, R Caraballo
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引用次数: 0

摘要

目的:确定一系列急性症状性癫痫发作的肿瘤儿科患者的临床、脑电图、治疗和演变特征:我们对2017-2021年间在血液肿瘤患者综合门诊中心接受神经内科评估的肿瘤儿科儿童的临床记录进行了回顾性和前瞻性描述性分析。我们纳入了1个月至17岁患有颅内和颅外肿瘤并出现急性症状性癫痫发作(ASC)的儿童。我们根据 2010 年国际抗癫痫联盟对急性症状性癫痫发作进行了定义。我们根据 2017 年国际抗癫痫联盟的分类对癫痫发作进行了分类。我们排除了任何既往诊断为癫痫和非癫痫性阵发性发作的患者:我们分析了 44 个病例,中位数为 4 年(范围:1 个月-17 年),平均为 5.75 个月(范围:1 个月-11 个月)和 8.33 年(2-17 年)。主要病因是神经毒性和手术后。四名患者出现了肢体运动障碍,两名患者伴有颅内高压。共进行了 41 次脑电图检查,临界结果为基线节律异常,但无病灶或阵发性发作。没有临界记录。病灶性癫痫发作有 25 例(56.8%),全身性癫痫发作有 19 例(43.18%)。左乙拉西坦是最常用的急性治疗药物:我们的队列显示,在这一人群中,ASC 在局灶性运动性发作和全身性发作之间并无明显差异,而且主要发生在神经毒性和手术后的情况下。此外,还记录到与 ASC 相关的肢体瘫痪和颅内高压。危机后的脑电图无病灶或阵发性发作,发作演变情况良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Acute symptomatic epileptic seizures. A clinical-electroencephalographic etiological description and prognosis of an oncopediatric series].

Aim: To determine clinical, electroencephalographic, therapeutic and evolutive characteristics of a series of oncopediatric patients with acute symptomatic seizures.

Patients and methods: We performed a retrospective and prospective descriptive analysis of clinical records of oncopediatric children evaluated by neurology at the comprehensive outpatient Center for Hemato-Oncological Patients during 2017-2021. We included children aged one month to 17 years with intracranial and extracranial tumors who presented with acute symptomatic seizure (ASC). We defined acute symptomatic seizure according to the 2010 International League Against Epilepsy. We classified seizures according to 2017 International League Against Epilepsy classification. We excluded any patient with a diagnosis of previous epilepsy and non-epileptic paroxysmal episodes.

Results: We analyzed 44 cases with a median of 4 years (range: 1 month-17 years) and mean of 5.75 months (range: 1 month-11 months) and 8.33 years (2-17 years). The main etiologies were neurotoxicity and post-surgical context. Four patients presented dysnatremias and two associated with endocranial hypertension. Forty-one electroencephalograms were performed with intercritical results with abnormalities in the baseline rhythm, but without foci or paroxysms. There were no critical recordings. Focal seizures were 25 (56.8%) and generalized seizures 19 (43.18%). Levetiracetam was the most commonly used drug for acute management.

Conclusions: Our cohort shows that ASC, in this population, do not show considerable differences between focal motor and generalized seizures and occur mostly in neurotoxic and post-surgical contexts. Dysnatremias and endocranial hypertension associated with ASC were also recorded. Postcrisis electroencephalograms were without foci or paroxysms and good seizure evolution.

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来源期刊
Revista de neurologia
Revista de neurologia 医学-临床神经学
CiteScore
2.50
自引率
8.30%
发文量
117
审稿时长
3-8 weeks
期刊介绍: Revista de Neurología fomenta y difunde el conocimiento generado en lengua española sobre neurociencia, tanto clínica como experimental.
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