多巴胺激动剂治疗垂体腺瘤患者的冲动控制障碍:一项横断面多中心研究。

IF 3.3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Pituitary Pub Date : 2024-04-01 Epub Date: 2024-02-12 DOI:10.1007/s11102-024-01383-2
Mussa H Almalki, Moayad A Alsuraikh, Eyad Almalki, Faisal Aziz, Raya Almazrouei, Khaled M AlDahmani, Fahad Alshahrani, Meshal Alaqeel, Moeber Mahzari, Aishah Ekhzaimy
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引用次数: 0

摘要

背景:冲动控制障碍(ICDs)已被描述为多巴胺激动剂(DAs)在神经系统疾病中未被充分认识的副作用,但在内分泌疾病中却未被充分认识:目的:在泌乳素瘤和非功能性垂体腺瘤(NFPA)患者中,确定DAs诱发ICD的患病率,并确定与这些疾病相关的潜在风险因素:这是一项横断面多中心研究,涉及 200 名泌乳素瘤和无功能垂体腺瘤患者,他们都在三级转诊中心接受了随访。使用根据以往研究修改的 ICD 问卷对泌乳素瘤引起的 ICD 进行评估:结果:52%的参与者报告了至少一种ICD,其中28.5%提到强迫购物,24.5%提到强迫打扑克,24.5%提到性欲亢进。此外,33%的患者报告有一种 ICD 行为,12%的患者报告有两种,7%的患者报告有三种。多变量逻辑回归显示,ICD 的重要风险因素是年龄较小(调整后的几率比 [AOR]:0.92,95% 置信区间):0.92,95% 置信区间 [CI]:0.88-0.97,P 0.001)、非未婚或单身(AOR:0.15,95%CI:0.03-0.84,P 0.03)和阳性精神病史(AOR:7.67,95%CI:1.37-42.97,P 0.021):结论:在接受泌乳素瘤和非泌乳素瘤治疗的患者中,伴有各种精神症状的 ICD 很常见。内分泌专家应注意这种潜在的副作用,尤其是对患者和有精神病史的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impulse control disorders in patients with dopamine agonist-treated pituitary adenomas: a cross-sectional multicenter study.

Background: Impulse control disorders (ICDs) have been described as underrecognized side effects of dopamine agonists (DAs) in neurological disorders but are not sufficiently understood in endocrine conditions.

Objective: To identify the prevalence of DAs induced ICDs and determine potential risk factors related to these disorders in patients with prolactinoma and non-function pituitary adenomas (NFPAs).

Methods: This is a cross-sectional multicenter study involving 200 patients with prolactinoma and NFPAs, who received follow-ups in tertiary referral centers. DA-induced ICDs were assessed using ICD questionnaires modified from prior studies.

Result: At least one ICD was reported by 52% of participants, among whom 28.5% mentioned compulsive shopping, 24.5% punding, and 24.5% hypersexuality. Furthermore, 33% of the patients reported the presence of one type of ICD behavior, while 12% specified two and 7% had three types of such behavior. The multivariable logistic regression showed that the significant risk factors of ICD were younger age (adjusted odds ratio [AOR]: 0.92, 95% confidence interval [CI]: 0.88-0.97, p 0.001), being single (AOR: 0.15, 95%CI: 0.03-0.84, p 0.03), and a positive history of psychiatric illness (AOR: 7.67, 95% CI: 1.37-42.97, p 0.021).

Conclusion: ICDs with a broad range of psychiatric symptoms are common in individuals with DA-treated prolactinoma and NFPAs. Endocrinologists should be aware of this potential side effect, particularly in patients with a personal history of psychiatric disorder.

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来源期刊
Pituitary
Pituitary 医学-内分泌学与代谢
CiteScore
7.10
自引率
7.90%
发文量
90
审稿时长
6 months
期刊介绍: Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease. The journal considers: Biology of Pituitary Tumors Mechanisms of Pituitary Hormone Secretion Regulation of Pituitary Function Prospective Clinical Studies of Pituitary Disease Critical Basic and Clinical Reviews Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.
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