{"title":"植物性食品摄入量与阿尔茨海默病之间的因果关系：孟德尔随机研究。","authors":"Xinmin Deng, Jingyi Zhu, Jingtao Liang, Wen Chang, Xiaofeng Lv, Rui Lai","doi":"10.1080/1028415X.2024.2312685","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a degenerative disease of the nervous system. Observational studies have found an association between plant food intake and AD. However, it is unclear whether this association is influenced by confounding factors. We aimed to explore the causal relationship between plant-based diet and the risk of AD using two-sample Mendelian randomization.</p><p><strong>Materials and methods: </strong>We obtained datasets of exposure from the IEU Open GWAS project, including dried fruit intake, fresh fruit intake, raw vegetable intake, cooked vegetable intake, and cereal intake. The summary data for AD were obtained from a large GWAS meta-analysis containing 71,880 cases and 383,378 controls.</p><p><strong>Results: </strong>Increased intake of dried fruits was associated with a reduced risk of AD (IVW: OR = 0.88, 95CI = 0.82-0.95). No causal association was found between the intake of other foods and AD.</p><p><strong>Conclusion: </strong>This MR study suggests that genetically predicted increased intake of dried fruits is a causal protective factor for AD.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1220-1225"},"PeriodicalIF":3.6000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study.\",\"authors\":\"Xinmin Deng, Jingyi Zhu, Jingtao Liang, Wen Chang, Xiaofeng Lv, Rui Lai\",\"doi\":\"10.1080/1028415X.2024.2312685\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Alzheimer's disease (AD) is a degenerative disease of the nervous system. Observational studies have found an association between plant food intake and AD. However, it is unclear whether this association is influenced by confounding factors. We aimed to explore the causal relationship between plant-based diet and the risk of AD using two-sample Mendelian randomization.</p><p><strong>Materials and methods: </strong>We obtained datasets of exposure from the IEU Open GWAS project, including dried fruit intake, fresh fruit intake, raw vegetable intake, cooked vegetable intake, and cereal intake. The summary data for AD were obtained from a large GWAS meta-analysis containing 71,880 cases and 383,378 controls.</p><p><strong>Results: </strong>Increased intake of dried fruits was associated with a reduced risk of AD (IVW: OR = 0.88, 95CI = 0.82-0.95). No causal association was found between the intake of other foods and AD.</p><p><strong>Conclusion: </strong>This MR study suggests that genetically predicted increased intake of dried fruits is a causal protective factor for AD.</p>\",\"PeriodicalId\":19423,\"journal\":{\"name\":\"Nutritional Neuroscience\",\"volume\":\" \",\"pages\":\"1220-1225\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutritional Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/1028415X.2024.2312685\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/2/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutritional Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1028415X.2024.2312685","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/12 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景：阿尔茨海默病（AD）是一种神经系统退行性疾病。观察性研究发现，植物性食物摄入量与阿尔茨海默病之间存在关联。然而，这种关联是否受混杂因素的影响尚不清楚。我们旨在利用双样本孟德尔随机法探讨植物性饮食与AD风险之间的因果关系：我们从 IEU Open GWAS 项目中获得了暴露数据集，包括干果摄入量、新鲜水果摄入量、生蔬菜摄入量、熟蔬菜摄入量和谷物摄入量。AD的汇总数据来自一项大型GWAS荟萃分析，其中包括71 880例病例和383 378例对照：结果：干果摄入量的增加与 AD 风险的降低有关（IVW：OR = 0.88，95CI = 0.82-0.95）。其他食物的摄入量与注意力缺失症之间没有因果关系：这项磁共振研究表明，根据基因预测，干果摄入量的增加是AD的一个因果保护因素。
Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study.
Background: Alzheimer's disease (AD) is a degenerative disease of the nervous system. Observational studies have found an association between plant food intake and AD. However, it is unclear whether this association is influenced by confounding factors. We aimed to explore the causal relationship between plant-based diet and the risk of AD using two-sample Mendelian randomization.
Materials and methods: We obtained datasets of exposure from the IEU Open GWAS project, including dried fruit intake, fresh fruit intake, raw vegetable intake, cooked vegetable intake, and cereal intake. The summary data for AD were obtained from a large GWAS meta-analysis containing 71,880 cases and 383,378 controls.
Results: Increased intake of dried fruits was associated with a reduced risk of AD (IVW: OR = 0.88, 95CI = 0.82-0.95). No causal association was found between the intake of other foods and AD.
Conclusion: This MR study suggests that genetically predicted increased intake of dried fruits is a causal protective factor for AD.
期刊介绍：
Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.
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