Guettarda uruguensis（茜草科）：含有槲皮素和对香豆酸酯的抗氧化和消炎植物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-19 DOI:10.1080/14786419.2024.2316321

Ana Flavia Schvabe Duarte , Daniela Maria Soares , Luciane Dalarmi , Mariana Saragiotto Krause , Fernanda Maria Marins Ocampos , Railson Henneber , Marilis Dallarmi Miguel , Deise Prehs Montrucchio , Obdulio Gomes Miguel

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引用次数: 0

摘要

Guettarda（茜草科）属植物因其多种多样的生物活性化合物而闻名，具有明显的抗炎和抗氧化特性。Guettarda uruguensis Cham. & Schltdl.俗称 "jasmim uruguaio "或 "veludinho"，是大西洋森林中的一种原生树种，其潜在的治疗用途引起了人们的兴趣。在这项研究中，我们评估了从 G. uruguensis 叶子中提取的粗乙醇提取物（EBGF）和馏分的酚含量和抗氧化活性，以及 EBGF 的抗痛、抗炎和毒性活性。我们的研究结果表明，EBGF 及其馏分含有多酚化合物，包括对香豆酸长链酯和槲皮素，这有助于它们发挥强大的抗氧化活性。EBGF 具有明显的抗炎和抗痛觉作用，突出了其作为治疗疼痛和炎症的天然产品的潜力。我们的研究证明，G. uruguensis 是一种具有药理潜力的生物活性化合物来源。

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Guettarda uruguensis (Rubiaceae): antioxidant and anti-inflammatory plant with quercetin and esters of p-coumaric acid

Guettarda (Rubiaceae) is a genus known for its diverse range of bioactive compounds, with demonstrated anti-inflammatory and antioxidant properties. Guettarda uruguensis Cham. & Schltdl., commonly known as ‘jasmim uruguaio’ or ‘veludinho,’ is a native species of the Atlantic Forest that get interested in its potential therapeutic applications. In this study, we evaluated the phenolic content and antioxidant activity of the crude ethanol extract obtained from G. uruguensis leaves (EBGF) and fractions, as well as the antinociceptive, anti-inflammatory, and toxicity activity of the EBGF. Our findings revealed that the EBGF and its fractions contain polyphenolic compounds, including long-chain esters of p-coumaric acid and quercetin, which contribute to their potent antioxidant activity. The EBGF exhibited significant anti-inflammatory and antinociceptive effects, highlighting its potential as a natural product for treating pain and inflammation. Our study supports G. uruguensis as a promising source of bioactive compounds with pharmacological potential.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.